Document Detail

Effects of four antioxidants on N-methyl-N'-nitro-N-nitrosoguanidine initiated gastric tumor development in rats.
MedLine Citation:
PMID:  3955537     Owner:  NLM     Status:  MEDLINE    
The effects of antioxidant administration during the post initiation phase of gastric tumor development were investigated in male Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Animals (20/group) were given MNNG in the drinking water (100 mg/l) for 8 weeks, and for the duration of this treatment were also fed on diet supplemented with 10% sodium chloride. Thereafter, they were divided into 6 groups and were maintained on diet containing either 2% butylated hydroxyanisole (BHA), 1% BHA, 1% butylated hydroxytoluene (BHT), 1% ethoxyquin (EQ) or 1% DL-alpha-tocopherol (alpha-TP) for 32 weeks. A carcinogen control group was fed the basal diet without antioxidant supplementation. The experiment was terminated 40 weeks after the beginning of administration of MNNG and development of gastroduodenal tumors was determined histopathologically. EQ significantly increased the incidence of tumors in the glandular stomach. No modification of tumor development in this region of the organ were observed with 2% BHA, 1% BHA, 1% BHT or 1% alpha-TP, although both 2% BHA and 1% BHA induced and/or promoted tumor development in the forestomach. In addition, nephrocalcinosis was identified only in the kidneys of rats given EQ after MNNG treatment.
M Takahashi; F Furukawa; K Toyoda; H Sato; R Hasegawa; Y Hayashi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  30     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-08     Completed Date:  1986-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  161-8     Citation Subset:  IM    
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MeSH Terms
Antioxidants / toxicity*
Butylated Hydroxyanisole / toxicity
Butylated Hydroxytoluene / toxicity
Duodenal Neoplasms / chemically induced,  pathology
Ethoxyquin / toxicity
Methylnitronitrosoguanidine / toxicity*
Rats, Inbred Strains
Stomach Neoplasms / chemically induced*,  pathology
Time Factors
Vitamin E / toxicity
Reg. No./Substance:
0/Antioxidants; 128-37-0/Butylated Hydroxytoluene; 1406-18-4/Vitamin E; 25013-16-5/Butylated Hydroxyanisole; 70-25-7/Methylnitronitrosoguanidine; 91-53-2/Ethoxyquin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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