Document Detail

Effects of four antihypertensive monotherapies on cardiac mass and function in hypertensive patients with left ventricular hypertrophy: randomized prospective study.
MedLine Citation:
PMID:  12476475     Owner:  NLM     Status:  MEDLINE    
AIM: To compare the effects of four antihypertensive drugs, which have reportedly different effectiveness in reducing myocardial mass. METHODS: A randomized, double-blind, prospective study included 80 hypertensive patients with left ventricular (LV) hypertrophy confirmed both electrocardiographically and echocardiographically. We investigated the effects of indapamide, nicardipine, propranolol, and chlorthalidone on arterial blood pressure and LV mass and function. RESULTS: Sixty-four patients (34 men and 30 women) completed the 6-month study. No significant differences in antihypertensive effects of the four medications were found. The average decrease in systolic and diastolic blood pressure was 12.8% and 10.4%, respectively. All four antihypertensive medications caused pronounced reduction in LV mass, between 7.9% in the propranolol group and 10.1% in the nicardipine group, with no significant difference between the groups. In patients receiving diuretics, predominant decrease was observed in LV mass and LV mass index. In patients treated with propranolol, the thickness of both the LV wall and interventricular septum was reduced, whereas the reduction in LV mass, LV wall and interventricular septum thickness was found in patients treated with nicardipine. There was no significant correlation between the changes in LV mass and other variables (blood pressure, and systolic and diastolic function). Systolic function did not improve with the reversion of LV hypertrophy in any group of patients, but improvement was observed in some indices of diastolic function. The early and late LV filling velocity and their ratio did not improve significantly, either. Clinically relevant side effects were not observed. CONCLUSION: All four antihypertensive monotherapies achieved a comparable control of hypertension and reduction in LV hypertrophy.
Drago Rakić; Zvonko Rumboldt; Jugoslav Bagatin; Stojan Polić
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Croatian medical journal     Volume:  43     ISSN:  0353-9504     ISO Abbreviation:  Croat. Med. J.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9424324     Medline TA:  Croat Med J     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  672-9     Citation Subset:  IM    
Department of Internal Medicine, Split University Hospital and School of Medicine, Split, Croatia.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use*
Chlorthalidone / pharmacology,  therapeutic use
Heart Ventricles / drug effects*,  physiopathology
Hypertension / complications,  drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / complications,  drug therapy*,  physiopathology
Indapamide / pharmacology,  therapeutic use
Middle Aged
Nicardipine / pharmacology,  therapeutic use
Organ Size / drug effects
Propranolol / pharmacology,  therapeutic use
Prospective Studies
Treatment Outcome
Ventricular Function, Left
Reg. No./Substance:
0/Antihypertensive Agents; 26807-65-8/Indapamide; 525-66-6/Propranolol; 55985-32-5/Nicardipine; 77-36-1/Chlorthalidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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