Document Detail

Effects of fostering on the increased tumor incidence produced by a maternal diet high in fat.
MedLine Citation:
PMID:  8844719     Owner:  NLM     Status:  MEDLINE    
Previous work has shown that female offspring of mice fed a diet high in fat during pregnancy developed more reproductive system tumors and metastases than offspring of pregnant mice fed a low-fat diet. The purpose of the current experiment was to use fostering to test whether the sensitive period for this cancer effect involved the early postnatal period. Strain CD-1 female mice were placed on a diet of 2.6% fat or 29% fat from corn oil at 4 weeks of age and bred at 6-10 weeks of age. The special diets were discontinued at birth, and litters from dams that had been fed the low-fat diet were fostered to dams previously fed the high-fat diet, and vice versa. The offspring were raised to terminal illness and autopsied. There was no difference in age at terminal illness or in the number of the common nonreproductive system tumors between the two fostered groups. Tumor metastases appeared in both groups. However, the combined frequency of reproductive tract tumors and mammary tumors was significantly higher in mice exposed prenatally to a low-fat diet and fostered to dams that had consumed a high-fat diet during pregnancy than in mice exposed prenatally to a high-fat diet and fostered to a dam fed a low-fat diet. Thus the most sensitive period for a cancer effect from high fat was early postnatal, even though the special diets had been discontinued at birth. This matches the period of greatest sensitivity for sex differentiation of the hypothalamus.
B E Walker; L A Kurth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutrition and cancer     Volume:  26     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-23     Completed Date:  1996-12-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Department of Anatomy, Michigan State University, East Lansing 48824-1316, USA.
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MeSH Terms
Dietary Fats / administration & dosage*
Genital Neoplasms, Female / etiology
Gestational Age
Liver Neoplasms / etiology,  pathology
Mammary Neoplasms, Experimental / etiology,  pathology
Neoplasm Metastasis
Neoplasms / etiology*
Ovarian Neoplasms / etiology,  pathology
Prenatal Exposure Delayed Effects*
Grant Support
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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