Document Detail


Effects of fosenopril, a once-daily angiotensin-converting enzyme inhibitor, on resting and exercise-induced changes of blood pressure, hormonal variables, and plasma potassium in essential hypertension.
MedLine Citation:
PMID:  2970855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fosenopril, a new angiotensin-converting enzyme (ACE) inhibitor, is a prodrug that is converted to its active diacid metabolite after intestinal absorption. Its excretion is equally divided between hepatic and renal routes. This study details the efficacy of fosenopril at rest and during exercise on blood pressure, plasma potassium, plasma renin activity, and plasma aldosterone in 11 hypertensive males, mean age 55 years. Individual subjects underwent an identical exercise protocol (bicycle ergometry) on placebo and on active treatment. Supine mean blood pressure fell from 116 to 100 mm Hg, P less than 0.005, and at 9 minutes of exercise mean blood pressure fell from 137 to 125 mm Hg, P less than 0.01 on fosenopril. Plasma potassium fell slightly at rest from 4.27 to 3.96 mmol/L and during exercise from 5.23 to 4.93 mmol/L, both P less than 0.025. Plasma renin activity (ng/mL/hr) rose on fosenopril, at rest 0.94 to 4.72, and during exercise 2.06 to 10.39, both P less than 0.005. Aldosterone changes on treatment were marginal and nonsignificant. The compound was well tolerated and free of subjective and routine laboratory side effects. Its antihypertensive action is broadly similar to the other ACE inhibitors currently available.
Authors:
P A Sullivan; M Dineen; J Cervenka; D T O'Connor
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  1     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-19     Completed Date:  1988-10-19     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280S-283S     Citation Subset:  IM    
Affiliation:
Mallow and Cork Regional Hospital, County Cork, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure*
Drug Administration Schedule
Fosinopril
Hormones / blood*
Humans
Hypertension / drug therapy*,  physiopathology
Middle Aged
Physical Exertion
Potassium / blood*
Proline / analogs & derivatives*,  therapeutic use
Renin / blood
Rest
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Hormones; 147-85-3/Proline; 52-39-1/Aldosterone; 7440-09-7/Potassium; 98048-97-6/Fosinopril; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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