Document Detail

Effects of footshock stress upon spleen and peripheral blood lymphocyte mitogenic responses in rats with lesions of the paraventricular nuclei.
MedLine Citation:
PMID:  8051296     Owner:  NLM     Status:  MEDLINE    
To assess the role of the hypothalamic paraventricular nucleus (PVN) in mediating stressor-induced immune alterations, male Lewis rats were subjected to a 1-h session of intermittent footshock stress or home cage conditions 6 days after receiving bilateral or sham PVN lesions. Splenic and peripheral blood lymphocyte proliferative responses to the non-specific mitogens, concanavalin A (ConA) and phytohemagglutinin (PHA), were subsequently measured as were plasma corticosterone levels. In sham-operated rats, footshock markedly elevated plasma corticosterone levels and concurrently suppressed the proliferative responses of peripheral blood and splenic lymphocytes. In PVN-lesioned rats, however, the shock-induced suppression of lymphocyte proliferation in the peripheral blood and the elevation of plasma corticosterone were significantly attenuated, while lymphocyte proliferation in the spleen was suppressed below the level of the sham-treated animals. Thus, by utilizing ablation studies, we have determined that the PVN may play a direct role in the alteration of lymphocyte function during stress, and an intact PVN buffers the effect of stress on the responsiveness of spleen lymphocytes to non-specific mitogens.
M A Pezzone; J Dohanics; B S Rabin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  53     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-09-08     Completed Date:  1994-09-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Department of Pathology, Brain, Behavior and Immunity Center, Pittsburgh, PA 15213-2582.
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MeSH Terms
Analysis of Variance
Corticosterone / blood
Corticotropin-Releasing Hormone / physiology
Hypothalamo-Hypophyseal System / physiology
Lymphocyte Activation*
Paraventricular Hypothalamic Nucleus / physiology*
Pituitary-Adrenal System / physiology
Rats, Inbred Lew
Spleen / immunology
Stress, Physiological / immunology*
Grant Support
Reg. No./Substance:
50-22-6/Corticosterone; 9015-71-8/Corticotropin-Releasing Hormone

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