Document Detail


Effects of food restriction on testis and accessory sex glands in maturing rats.
MedLine Citation:
PMID:  18648097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reduced food consumption and associated lower body weights may occur in subacute toxicity studies. The short-term effects of food restriction (FR) on body and reproductive organ weights, hormones, and testis histology were assessed in Sprague-Dawley rats fed 20% to 36% less (21 g feed/day) than rats fed ad libitum (AL) starting at six, eight, ten, or twelve weeks of age for two or six weeks. Body weight and relative seminal vesicle, ventral prostate, and/or epididymis weights were reduced in rats FR for two or six weeks. Degeneration of stage VII pachytene spermatocytes was seen in rats FR for six weeks when initiated at eight, ten, and twelve weeks of age. Plasma testosterone concentrations were lower in rats FR at ages six to eight weeks, eight to ten weeks, six to twelve weeks, and eight to fourteen weeks. Luteinizing hormone was not statistically different in FR rats compared with AL counterparts. Therefore, duration of lower food intake had a greater impact on spermatogenesis, whereas a younger initial age of lower food intake was more influential on testosterone levels. These interactions are important in the interpretation of subacute toxicology studies employing FR or when test articles lower food consumption relative to AL-fed rats.
Authors:
Sabine Rehm; Tacey E White; Eias A Zahalka; Dinesh J Stanislaus; Rogely W Boyce; Patrick J Wier
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Publication Detail:
Type:  Journal Article     Date:  2008-07-22
Journal Detail:
Title:  Toxicologic pathology     Volume:  36     ISSN:  1533-1601     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-10-16     Revised Date:  2012-01-05    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-94     Citation Subset:  IM    
Affiliation:
GlaxoSmithKline, King of Prussia, Pennsylvania 19301, USA. veterinarypathology102@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Epididymis / drug effects*,  pathology
Food Deprivation*
Male
Organ Size / drug effects
Prostate / drug effects*,  pathology
Rats
Rats, Sprague-Dawley
Seminal Vesicles / drug effects*,  pathology
Spermatocytes / drug effects,  pathology
Testis / drug effects*,  pathology
Testosterone / blood
Time Factors
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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