Document Detail

Effects of food restriction on the length of lactational diestrus in rats.
MedLine Citation:
PMID:  2045092     Owner:  NLM     Status:  MEDLINE    
The effect of food restriction (60% of an ad lib ration) for the first 14 days postpartum on serum progesterone levels and the duration of lactational diestrus was determined in rat dams nursing litters of eight pups. Food restricted dams showed a longer period of lactational diestrus than ad lib fed dams. Food restriction also caused an increase in progesterone levels that was maintained beyond the period of food restriction itself. Treatment with the dopamine agonist bromocryptine mesylate (0.5 mg/day) either from Day 1 or Day 9 postpartum onward induced early termination of lactational diestrus in both ad lib and food restricted dams but the effect was more rapid in the ad lib fed than in the food restricted females. In both cases, however, the effects of bromocryptine administration on milk delivery showed a similar time course providing indirect evidence that prolactin suppression was equivalent under both diet conditions. These data suggest that food restriction during lactation results in increased progesterone levels that most likely result from increased prolactin release. Further, while prolactin suppression in food restricted dams reduces the duration of lactational diestrus, the latency to do so is somewhat longer than that seen in ad lib fed females, suggesting that some other mechanism may also be operating to suppress ovulation in the food restricted female.
B Woodside
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormones and behavior     Volume:  25     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-16     Completed Date:  1991-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-83     Citation Subset:  IM    
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bromocriptine / pharmacology
Diestrus / drug effects,  physiology*
Dopamine / physiology
Energy Intake / drug effects,  physiology*
Food Deprivation / physiology*
Lactation / drug effects,  physiology*
Ovulation / drug effects,  physiology*
Progesterone / blood*
Prolactin / physiology
Rats, Inbred Strains
Reg. No./Substance:
25614-03-3/Bromocriptine; 57-83-0/Progesterone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of vasotocin on locomotor activity in bullfrogs varies with developmental stage and sex.
Next Document:  Effects of surgical deafening and exposure to continuous darkness on cloacal gland size in scotorefr...