Document Detail

The effects of food presentation at regular or irregular times on the development of activity-based anorexia in rats.
MedLine Citation:
PMID:  20176093     Owner:  NLM     Status:  MEDLINE    
Activity-based anorexia occurs when food availability is restricted to 1h of the day and a wheel is freely available to the rest of the time. Under such conditions rats run excessively and stop eating even during periods in which food is available. A defining characteristic of the excessive activity is that there is a peak of running in the anticipation of food availability. The present study was designed to test whether the occurrence of the food period at different times of the light phase of the light-dark cycle (from 08:00 to 20:00h) could impede or postpone the normal development of activity anorexia. We compared the effect of presenting the food at a fixed time of the light period with presenting it on a variable schedule. Far from impeding or postponing the development of activity-based anorexia, presenting food at irregular times resulted in a pronounced body-weight loss, a low food intake and an increase in locomotor activity. Animals ran excessively, with a peak at the start of the dark period, and again when lights were turned on in the experimental room (running in the anticipation of food). Both fixed and variable schedules of food availability resulted in the development of activity-based anorexia in rats.
Angeles Pérez-Padilla; Paula Magalhães; Ricardo Pellón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-20
Journal Detail:
Title:  Behavioural processes     Volume:  84     ISSN:  1872-8308     ISO Abbreviation:  Behav. Processes     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-19     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  541-5     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier B.V. All rights reserved.
Animal Behavior Lab, Departamento de Psicología Básica I, Facultad de Psicología, Universidad Nacional de Educación a Distancia, Madrid, Spain.
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MeSH Terms
Analysis of Variance
Anorexia / psychology*
Drinking Behavior
Feeding Behavior*
Motor Activity*
Rats, Wistar
Reinforcement Schedule*
Time Factors
Weight Loss

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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