Document Detail

Effects of food deprivation on cocaine base smoking in rhesus monkeys.
MedLine Citation:
PMID:  7659759     Owner:  NLM     Status:  MEDLINE    
Studies have shown that both food deprivation and response cost have important influences on the magnitude of self-administration of a wide variety of psychoactive drugs. In an attempt to extend these findings to the smoked route of drug self-administration, the effects of food allotment and fixed-ratio (FR) value were evaluated in four male rhesus monkeys trained to smoke cocaine base. In the first phase of the experiment, monkeys were trained to self-administer experiment, monkeys were trained to self-administer smoked cocaine base under a chained progressive-ratio (PR), fixed-ratio (FR) schedule during daily experimental sessions. Monkeys were required to make 20 lever-press responses and then five inhalations on a smoking spout to obtain the first smoke delivery. The lever ratio than increased to 60, 140, 300, 620, 1260, 2540, and 4940 for each successive smoke delivery. The initial lever ratio value was reset to 20 at the beginning of each daily session. The body weights of three monkeys were determined under free-feeding conditions. Monkeys were then restricted to 100 g food and, when body weights had stabilized, the daily food allotment was increased to 150 g, approximately 210 g, or greater than 400 g (satiation). As the daily food allotment and body weight increased, the mean number of smoke deliveries decreased in two of three monkeys. In the second phase of the experiment, three monkeys were maintained under either food-satiated or food-restricted conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
S D Comer; D M Turner; M E Carroll
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  119     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-03     Completed Date:  1995-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
Department of Psychiatry, University of Minnesota, Medical School, Minneapolis 55455, USA.
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MeSH Terms
Behavior, Animal*
Body Weight
Conditioning, Operant
Crack Cocaine*
Food Deprivation*
Macaca mulatta
Reinforcement Schedule
Self Administration*
Smoking / psychology*
Substance-Related Disorders / psychology
Time Factors
Grant Support
1PO1 08131//PHS HHS; 1RO1 DA 07716/DA/NIDA NIH HHS; R29 DA 07097/DA/NIDA NIH HHS
Reg. No./Substance:
0/Crack Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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