Document Detail


Effects of fluvoxamine on ethanol-reinforced behavior in the rat.
MedLine Citation:
PMID:  11356922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serotonergic deficiencies have been associated with alcoholism, and increasing serotonin function has been reported to decrease ethanol consumption. In this study, we examined the effects of the selective serotonin reuptake inhibitor, fluvoxamine, upon ethanol self-administration in the rat, and as a test of specificity also examined the effects of fluvoxamine upon food-maintained behavior. Fluvoxamine decreased ethanol-maintained (0.1 ml per dipper presentation, 4-32% w/v ethanol) behavior at lower doses than the doses needed to decrease food-maintained (2 x 45-mg pellet) behavior. Examination of the behavioral interactions of ethanol and fluvoxamine upon food-maintained behavior showed that these observations did not result from synergistic behavioral actions that would occur during ethanol-maintained, but not food-maintained, behavior. Also, fluvoxamine did not alter the potency or efficacy of ethanol to occasion ethanol-appropriate responding in rats trained to discriminate 1.2 g/kg ethanol from vehicle. These findings suggest that fluvoxamine has specific actions upon the reinforcing effects of ethanol.
Authors:
R J Lamb; T U Järbe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  297     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1001-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. lamb@UTHSCSA.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects*
Conditioning, Operant / drug effects
Dextroamphetamine / pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Ethanol / administration & dosage*
Feeding Behavior / drug effects
Fluvoxamine / administration & dosage*
Male
Rats
Rats, Inbred Lew
Reaction Time / drug effects
Reinforcement (Psychology)*
Self Administration
Serotonin Uptake Inhibitors / administration & dosage*
Tetrahydrocannabinol / pharmacology
Grant Support
ID/Acronym/Agency:
DA 00253/DA/NIDA NIH HHS; DA 09064/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 1972-08-3/Tetrahydrocannabinol; 51-64-9/Dextroamphetamine; 54739-18-3/Fluvoxamine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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