Document Detail


Effects of flutamide and aminoglutethimide on plasma 5 alpha-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate.
MedLine Citation:
PMID:  2961945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma levels of androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-diol-G) and androsterone glucuronide (ADT-G) have been found to be effective markers of C-19 steroid metabolism in periphery in man. The present study has been performed in order to study in castrated patients the effect of antiandrogen administered alone or in combination with aminoglutethimide (AG) on the metabolism of adrenal C-19 steroid. Ten castrated patients with prostatic cancer received flutamide (FLU) alone for 2 months and, afterwards, the combined therapy of FLU and AG for 2 months. Antiandrogen treatment alone reduces the levels of dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone glucuronide (DHEA-G) and androstenedione (4-ene-dione) by 43, 34 and 38% (P less than or equal to 0.01) respectively while dehydroepiandrosterone (DHEA), androst-5-ene-3 beta,17 beta-diol (5-ene-diol) and androst-5-ene-3 beta,17 beta-diol-glucuronide (5-ene-diol-G) levels show a nonsignificant inhibition. In these patients, plasma 3 alpha-diol-G and ADT-G concentrations are nonsignificantly stimulated to 122 and 143%. Moreover, when patients were receiving the combined administration of FLU and AG, adrenal C-19 steroids were further inhibited while both 3 alpha-diol-G and ADT-G show a small but nonsignificant decrease. Our data indicate that the antiandrogen increases the formation and/or the metabolism of adrenal C-19 steroids into steroid glucuronides.
Authors:
M Brochu; A Bélanger; A Dupont; L Cusan; F Labrie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of steroid biochemistry     Volume:  28     ISSN:  0022-4731     ISO Abbreviation:  J. Steroid Biochem.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-02-20     Completed Date:  1988-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0260125     Medline TA:  J Steroid Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  619-22     Citation Subset:  IM    
Affiliation:
Laboratory of Molecular Endocrinology, Laval Hospital Center, Ste-Foy, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aminoglutethimide / pharmacology*
Androstane-3,17-diol / analogs & derivatives,  blood*
Androstanols / blood*
Androsterone / analogs & derivatives*,  blood
Anilides / pharmacology*
Dehydroepiandrosterone / analogs & derivatives,  blood*
Dehydroepiandrosterone Sulfate
Flutamide / pharmacology*
Glucuronates / blood*
Humans
Male
Middle Aged
Orchiectomy*
Prostatic Neoplasms / blood*
Chemical
Reg. No./Substance:
0/Androstanols; 0/Anilides; 0/Glucuronates; 125-84-8/Aminoglutethimide; 13311-84-7/Flutamide; 1852-43-3/androsterone glucuronide; 25126-76-5/Androstane-3,17-diol; 27195-25-1/androstane-3,17-diol glucuronide; 53-41-8/Androsterone; 53-43-0/Dehydroepiandrosterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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