| Effects of fluoxetine and norfluoxetine on 5-hydroxytryptamine metabolism in blood platelets and brain after administration to rats. | |
| | |
MedLine Citation:
|
PMID: 10052854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of intraperitoneal administration of fluoxetine (2.5, 5, 10 or 20 mg kg(-1)) and norfluoxetine (10 mg kg(-1)) on 5-hydroxytryptamine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) metabolism were examined in the blood platelets and brain of rats killed 3 h after a single dose. Several experiments were performed to evaluate the effect of norfluoxetine. Plasma 5-HT concentrations decreased significantly (48%) compared with control group results 3 h after administration of a single dose of fluoxetine (10 or 20 mg kg(-1)). Similar plasma 5-HT levels, 0.54+/-0.04 and 0.56+/-0.09 mg L(-1), respectively, were observed after administration of 10 mg kg(-1) fluoxetine or norfluoxetine. In the same way 5-HIAA levels in whole brain were similar, 0.36+/-0.03 and 0.34+/-0.01 microg(-1), respectively, after administration of fluoxetine or norfluoxetine. There was a good correlation between plasma and brain levels of fluoxetine (0.962) and norfluoxetine (0.957). The results suggest that fluoxetine and norfluoxetine lead to reduced levels of 5-HT in platelets and of 5-HIAA in the brain. Like the parent drug, norfluoxetine is a potent and selective inhibitor of 5-HT uptake. |
| | |
Authors:
|
R Bourdeaux; D Desor; P R Lehr; C Younos; B Capolaghi |
Related Documents
:
|
6174894 - Ketamine inhibits serotonin synthesis and metabolism in vivo. 17105934 - Neural effects of mdma as determined by functional magnetic resonance imaging and magne... 2905784 - Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesi... 19576924 - Prx-00023, a selective serotonin 1a receptor agonist, reduces ultrasonic vocalizations ... 9024174 - Dup 532, an angiotensin ii receptor antagonist: first administration and comparison wit... 18373654 - Effect of baclofen on oesophageal motility and transient lower oesophageal sphincter re... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of pharmacy and pharmacology Volume: 50 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1998 Dec |
Date Detail:
|
Created Date: 1999-04-29 Completed Date: 1999-04-29 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1387-92 Citation Subset: IM |
Affiliation:
|
Laboratoire de Biochimie, CHR Metz-Thionville, Thionville, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antidepressive Agents, Second-Generation / pharmacology Blood Platelets / drug effects*, metabolism Brain / drug effects*, metabolism Fluoxetine / analogs & derivatives*, pharmacology* Hydroxyindoleacetic Acid / blood, metabolism Injections, Intraperitoneal Male Rats Rats, Wistar Serotonin / blood, metabolism* Serotonin Uptake Inhibitors / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Antidepressive Agents, Second-Generation; 0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 54910-89-3/Fluoxetine; 56161-73-0/norfluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of tamoxifen on striatal dopamine and 5-hydroxytryptamine release in freely moving male rats...
Next Document: Pharmacokinetic interaction in rabbits between a new anticonvulsant, DL-3-hydroxy-3-ethyl-3-phenylpr...