Document Detail

Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity.
MedLine Citation:
PMID:  20403372     Owner:  NLM     Status:  In-Process    
The present study investigated the effects of the SSRI fluoxetine and the serotonin synthesis blocker - parachlorophenylalanine (PCPA) on morphine self-administration and startle reactivity in rats subjected to social isolation during adulthood. Adult Wistar rats were housed individually or in pairs for 21days. They were treated with fluoxetine, PCPA, or vehicle and tested for their startle response and intake of a morphine solution (0.5mg/ml). Socially restricted rats consumed significantly more morphine solution (but not water) than rats living in pairs, in both one-bottle and in two-bottle tests. They also showed significantly higher startle response amplitude. Daily fluoxetine treatment (5mg/kg i.p.) counteracted these behavioral alterations induced by isolation housing while PCPA treatment (200mg/kg for 3 consecutive days) further exacerbated it. Social isolation may increase morphine self-administration and emotional reactivity in the startle box by affecting serotonin. Antidepressants (such as fluoxetine) may normalize or stabilize serotonin function and restore the behavioral changes produced by isolation.
S Raz; B D Berger
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-18
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  96     ISSN:  1873-5177     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
The Center for Psychobiological Research, Department of Psychology, The Academic College of Emek Yezreel, Emek Yezreel 19300, Israel.
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