Document Detail

Effects of fluorides on Candida albicans.
MedLine Citation:
PMID:  18410574     Owner:  NLM     Status:  MEDLINE    
AIMS: To assess whether a short exposure of Candida albicans to commonly used fluorides would affect growth, cell surface hydrophobicity, and adherence to buccal epithelial cells. METHODS: Candida albicans ATCC 90028 and 11 clinical isolates were used. Minimal inhibitory concentrations (MICs) of sodium fluoride (NaF) and of an amine fluoride / stannous fluoride combination (AmF / SnF2) were determined. Yeasts were exposed to MICs of tested agents for 1 h. Subsequently, their growth was recorded spectrophotometrically. Their cell surface hydrophobicity was assessed with n-hexadecane. Adherence to buccal epithelial cells was determined microscopically. Phosphate buffered saline (PBS) and chlorhexidine digluconate (CHX) served as controls. All results were analyzed by one-way ANOVA. RESULTS: MICs of AmF / SnF(2) and CHX varied between 1 and 4 microg ml(-1), whereas those of NaF were 15 000 microg ml(-1). Statistically significant growth inhibition was detected after AmF / SnF(2) (OD(24 h) +/- SD 0.457 +/- 0.059) and CHX (0.175 +/- 0.065) in comparison with PBS (0.925 +/- 0.087) and NaF (0.813 +/- 0.081). All strains demonstrated uniform behavior. Only minor changes in cell surface hydrophobicity and adherence to buccal epithelial cells (BEC) were detected. CONCLUSION: Growth inhibition of AmF / SnF(2) was comparable with that of CHX whereas NaF had a weaker effect. Exposure to the fluorides did not seem to alter the cell surface hydrophobicity nor adherence to BEC.
S Flisfisch; J Meyer; J H Meurman; T Waltimo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oral diseases     Volume:  14     ISSN:  1601-0825     ISO Abbreviation:  Oral Dis     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-15     Completed Date:  2008-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  D    
Institute of Preventive Dentistry and Oral Microbiology, School of Dentistry, University of Basel, Basel, Switzerland.
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MeSH Terms
Amines / pharmacology*
Analysis of Variance
Antifungal Agents / pharmacology*
Candida albicans / drug effects*
Cell Adhesion / drug effects
Cells, Cultured
Chlorhexidine / pharmacology
Drug Combinations
Epithelial Cells
Microbial Sensitivity Tests
Mouth Mucosa / cytology
Sodium Fluoride / pharmacology*
Tin Fluorides / pharmacology*
Reg. No./Substance:
0/Amines; 0/Antifungal Agents; 0/Drug Combinations; 0/Tin Fluorides; 37334-68-2/amine fluoride gel; 55-56-1/Chlorhexidine; 7681-49-4/Sodium Fluoride

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