| Effects of fluorides on Candida albicans. | |
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MedLine Citation:
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PMID: 18410574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To assess whether a short exposure of Candida albicans to commonly used fluorides would affect growth, cell surface hydrophobicity, and adherence to buccal epithelial cells. METHODS: Candida albicans ATCC 90028 and 11 clinical isolates were used. Minimal inhibitory concentrations (MICs) of sodium fluoride (NaF) and of an amine fluoride / stannous fluoride combination (AmF / SnF2) were determined. Yeasts were exposed to MICs of tested agents for 1 h. Subsequently, their growth was recorded spectrophotometrically. Their cell surface hydrophobicity was assessed with n-hexadecane. Adherence to buccal epithelial cells was determined microscopically. Phosphate buffered saline (PBS) and chlorhexidine digluconate (CHX) served as controls. All results were analyzed by one-way ANOVA. RESULTS: MICs of AmF / SnF(2) and CHX varied between 1 and 4 microg ml(-1), whereas those of NaF were 15 000 microg ml(-1). Statistically significant growth inhibition was detected after AmF / SnF(2) (OD(24 h) +/- SD 0.457 +/- 0.059) and CHX (0.175 +/- 0.065) in comparison with PBS (0.925 +/- 0.087) and NaF (0.813 +/- 0.081). All strains demonstrated uniform behavior. Only minor changes in cell surface hydrophobicity and adherence to buccal epithelial cells (BEC) were detected. CONCLUSION: Growth inhibition of AmF / SnF(2) was comparable with that of CHX whereas NaF had a weaker effect. Exposure to the fluorides did not seem to alter the cell surface hydrophobicity nor adherence to BEC. |
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Authors:
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S Flisfisch; J Meyer; J H Meurman; T Waltimo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Oral diseases Volume: 14 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-15 Completed Date: 2008-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 296-301 Citation Subset: D |
Affiliation:
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Institute of Preventive Dentistry and Oral Microbiology, School of Dentistry, University of Basel, Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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pharmacology* Analysis of Variance Antifungal Agents / pharmacology* Candida albicans / drug effects* Cell Adhesion / drug effects Cells, Cultured Cheek Chlorhexidine / pharmacology Drug Combinations Epithelial Cells Humans Hydrophobicity Microbial Sensitivity Tests Mouth Mucosa / cytology Sodium Fluoride / pharmacology* Tin Fluorides / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Antifungal Agents; 0/Drug Combinations; 0/Tin Fluorides; 37334-68-2/amine fluoride gel; 55-56-1/Chlorhexidine; 7681-49-4/Sodium Fluoride |
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