Document Detail

Effects of fluid resuscitation on total fluid loss following thermal injury.
MedLine Citation:
PMID:  7209772     Owner:  NLM     Status:  MEDLINE    
Plasma volume loss, cardiac output and hematocrit values have been measured in anesthetized dogs receiving a 15 per cent total body surface area third degree flame burn before and two, four and six hours postburn. One group of dogs received no fluid resuscitation. Five groups of dogs received fluid resuscitation with varying percentages of albumin added to the Ringer's lactate solution. Results of this study show that total fluid loss from the vascular bed increased as the result of fluid resuscitation. The amount of increase in total fluid loss was dependent upon the percentage of albumin in the resuscitation fluid. The higher the percentage of albumin, the lower the amount of total fluid loss. Following fluid resuscitation, cardiac output improved and the hematocrit level decreased toward normal. The amount of change of these variables was also related to the percentage of albumin in the resuscitation fluid. The greatest improvement in these variables was observed in that group of dogs receiving the greatest percentage of albumin in the resuscitation fluid. These results demonstrate that the administration of resuscitation fluid improves cardiovascular function following thermal injury and that the amount of improvement is related to the percentage of albumin present in fluid used for resuscitation.
J G Hilton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  152     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-05-26     Completed Date:  1981-05-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  441-7     Citation Subset:  AIM; IM    
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MeSH Terms
Burns / blood,  physiopathology,  therapy*
Cardiac Output
Fluid Therapy / methods*
Plasma Volume*
Serum Albumin / administration & dosage
Reg. No./Substance:
0/Serum Albumin

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