Document Detail


Effects of flow and energy metabolism on injury and Rb(+) uptake in pig hearts: an (87)Rb and (31)P NMR study.
MedLine Citation:
PMID:  11675649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this work the roles of coronary flow (CF) and metabolism in Rb(+) (K(+) congener) uptake were studied. In isolated pig hearts the left anterior descending artery (LAD) was cannulated to maintain adequate perfusion of the LAD bed. Rb(+) loading was initiated and the LAD flow was either completely stopped (no flow (NF)) or reduced to 12% (low flow (LF)), or buffer was deoxygenated without change in flow (hypoxic flow (HYP)) for 2 h. CF through the LAD was then restored to normal, or perfusion was switched to oxygenated buffer. Serial (87)Rb MR images or localized (31)P spectra were acquired to compare the Rb(+) uptake and energetics in the left ventricular (LV) anterior (ischemic/hypoxic) and posterior (normal) walls. End-ischemic/hypoxic (87)Rb signal intensities in the anterior wall were higher and the fluxes were greater in the HYP and LF groups than in the NF group. Phosphocreatine and ATP decreased less significantly and recovered better in the HYP and LF groups. Upon reperfusion/reoxygenation, the HYP and LF groups showed higher (87)Rb signal intensities and smaller or no infarctions in the anterior wall compared to those in the NF group. Ischemia reduces Rb(+) uptake due to both flow limitations and metabolic inhibition of cellular transport. (87)Rb MRI has a potential for distinguishing necrotic and reversibly damaged tissue.
Authors:
V V Kupriyanov; B Xiang; J Sun; O Jilkina; G Dai; R Deslauriers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  46     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-24     Completed Date:  2001-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  963-73     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, Manitoba, Canada. Kupriyanov@IBD.NRC.CA
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Circulation*
Energy Metabolism*
Magnetic Resonance Imaging*
Magnetic Resonance Spectroscopy / diagnostic use*
Myocardial Reperfusion Injury / metabolism*,  physiopathology
Myocardium / metabolism*
Rubidium / diagnostic use
Rubidium Radioisotopes / diagnostic use
Swine
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Rubidium Radioisotopes; 7440-17-7/Rubidium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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