| Effects of flavangenol, an extract of French maritime pine bark on collagen-induced arthritis in rats. | |
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MedLine Citation:
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PMID: 21908949 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Flavangenol (FG), an extract of French maritime pine bark (Pinus maritime) mainly contains proanthocyanidin in oligomers. It has many physiological effects, including antioxidant and anti-atherosclerosis. In this study, we evaluated the effects of FG on rat collagen-induced arthritis, a model of human rheumatoid arthritis. The rats were fed with the diet of control, 0.3% FG, or 1% FG for 4 wk after the induction of arthritis. The FG diets, compared with the control diet, suppressed the increase in arthritic score and swelling of the paws in a dose-dependent manner. Histopathological examination revealed evidence that the 1% FG diet suppressed acute and chronic articular lesions in the rats. In addition, the FG diets (0.3% and 1%) suppressed the production of nitric oxide in the plasma of the rats. These results suggest that dietary FG has beneficial effects on collagen-induced arthritis in rats by inhibiting the acute and chronic inflammatory reactions. |
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Authors:
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Masahito Tsubata; Kinya Takagaki; Shin-Ichi Hirano; Koichi Iwatani; Chiyuki Abe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 57 ISSN: 1881-7742 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Affiliation:
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Research and Development Division, Toyo Shinyaku Co., Ltd. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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