Document Detail

Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status.
MedLine Citation:
PMID:  16179409     Owner:  NLM     Status:  MEDLINE    
Circulating levels of the orexigenic peptide ghrelin increase during fasting and decrease with refeeding. Exogenous ghrelin administration is a potent stimulus for food intake in rodents and humans. In subjects on fixed feeding schedules, ghrelin increases before each meal, raising the possibility that anticipation of meals, in addition to effects of fasting and feeding, contributes to ghrelin secretion. To distinguish among these regulatory influences, plasma ghrelin profiles were generated in freely fed rats and in meal-fed rats trained to consume their daily calories over a 4-h period in the light phase. In freely feeding rats, plasma ghrelin levels increased to a peak of 778 +/- 95 pg/ml just before the onset of the dark. Similarly, in meal-fed rats anticipating a large meal of either chow or Ensure at their usual feeding time, plasma ghrelin increased steadily over the 2 h preceding the meal to peaks of 2192 +/- 218 and 2075 +/- 92 pg/ml, respectively. When freely fed rats were food deprived for a time equivalent to meal-fed rats, there was no peak of plasma ghrelin. In addition, eating-induced suppression of the ghrelin response differed significantly between meal-fed rats and ad libitum-fed rats receiving meals of similar size. These findings indicate that anticipation of eating, as well as fasting/feeding status, influences pre- and postprandial plasma ghrelin levels in rats. Together, these data are consistent with a role for ghrelin in the regulation of anticipatory processes involved in food intake and nutrient disposition.
Deborah L Drazen; Torsten P Vahl; David A D'Alessio; Randy J Seeley; Stephen C Woods
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-09-22
Journal Detail:
Title:  Endocrinology     Volume:  147     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  AIM; IM    
Department of Psychiatry, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio 45267, USA.
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MeSH Terms
Dietary Fats / pharmacology
Eating / physiology*
Energy Intake / physiology
Learning / physiology*
Models, Animal
Peptide Hormones / blood,  secretion*
Postprandial Period / physiology
Rats, Long-Evans
Grant Support
17844//PHS HHS; 54080//PHS HHS; 56863//PHS HHS; DK 63779/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Dietary Fats; 0/Ghrelin; 0/Peptide Hormones
Comment In:
Endocrinology. 2006 Jan;147(1):20-2   [PMID:  16365141 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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