Document Detail

Effects of fish oil supplementation in late pregnancy on blood pressure: a randomised controlled trial.
MedLine Citation:
PMID:  8645644     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effect of fish oil supplementation on blood pressure during the third trimester of pregnancy. DESIGN: In the 30th week of pregnancy 533 healthy women were randomly assigned in a ratio 2:1:1 to receive fish oil (2.7 g/day n-3 fatty acids (Pikasol)), or a control regimen of either olive oil or no oil supplementation. MAIN OUTCOME MEASURES: Blood pressure measured with an automatic device (Dinamap 1846 SX, Criticon) at baseline and in weeks 33, 37, 39 and subsequently weekly until delivery. RESULTS: Mean blood pressure increased during the third trimester, and this was not influenced by group assignment. No significant effects on either systolic or diastolic blood pressure were seen in the fish oil group compared to the control groups. The proportions of women with a systolic blood pressure above 140 mmHg or a diastolic blood pressure above 90 mmHg were not significantly different in the fish oil group compared with the control groups, although the proportion of women with diastolic above 90 mmHg tended to be lower in the fish oil group compared with the olive oil group. The corresponding relative risk was RR = 0.48 (95% CI 0.22-1.06; P = 0.07). CONCLUSION: 2.7 g/day of marine n-3 fatty acids provided in the third trimester of normal pregnancy showed no effect on blood pressure.
J D Salvig; S F Olsen; N J Secher
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  103     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University Hospital of Aarhus, Denmark.
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MeSH Terms
Blood Pressure / physiology*
Fatty Acids, Omega-3
Fatty Acids, Unsaturated / administration & dosage*
Fish Oils / administration & dosage*
Hypertension / diet therapy
Pregnancy / physiology*
Pregnancy Complications, Cardiovascular / diet therapy
Pregnancy Trimester, Third
Triglycerides / administration & dosage*
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Triglycerides; 100085-40-3/Pikasol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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