| Effects of first and second generation calcium channel blockers on diastolic function of the failing hamster heart: relationship with coronary flow changes. | |
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MedLine Citation:
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PMID: 12827040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcium channel blockers (CCBs) have variable efficacy in the treatment of heart failure. We hypothesized that modulation of left ventricular diastolic pressure (LVDP) may play a role in the variable efficacy of CCBs in this condition. Isolated perfused hearts from 200- to 250-day-old UM-X7.1 cardiomyopathic hamsters (failing hearts) and age-matched Syrian hamsters (normal hearts) were studied. After recording of heart rate, coronary flow (CF), LVDP and left ventricular systolic pressure (LVSP), hearts were exposed either to verapamil or diltiazem (1 nM-10 microM), mibefradil (1 nM-1 microM) or clentiazem (1 nM-10 microM). Mechanical increase in CF (+2 to +10 ml/min) was carried out using a roller pump. Mechanically-augmented flow led to an increase in coronary perfusion pressure (+40 to +90 mm Hg), LVSP (+5 to +40 mm Hg) and LVDP (+5 to +25 mm Hg). CCBs-induced increment of coronary flow led to a difference in their cardiac response. In normal hearts, the negative inotropic response was more important with diltiazem and verapamil. Failing hearts did not demonstrate increased inotropic sensitivity to first-generation CCBs. On the contrary, at clinically relevant concentrations, verapamil resulted in the most pronounced impairment of LVDP followed by diltiazem while mibefradil and clentiazem, at clinically relevant concentrations, preserved LVDP. Such findings provide an additional explanation for the variable efficacy of CCBs in heart failure. |
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Authors:
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Pierre Beaucage; Julie Massicotte; Jean-François Boileau; Louis Dumont |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 42 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-26 Completed Date: 2003-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 142-50 Citation Subset: IM |
Affiliation:
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Départements de pharmacologie, Faculté de médecine, Université de Montréal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Calcium Channel Blockers / pharmacology* Cardiac Output, Low / physiopathology* Coronary Circulation / drug effects*, physiology Cricetinae Heart* / drug effects, physiopathology Ventricular Function, Left / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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