Document Detail


Effects of finasteride and bicalutamide on prostatic blood flow in the rat.
MedLine Citation:
PMID:  10792183     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether finasteride and bicalutamide, both currently used in the clinical management of patients with prostate diseases because they have anti-androgenic properties, have any effects on prostatic blood flow in a rat prostate model, as androgens are known to be involved in the regulation of prostatic blood flow and angiogenesis. MATERIALS AND METHODS: Both finasteride and bicalutamide were supplied as oral suspensions in water and given daily to rats for 7 days by tube feeding. Blood flows to the ventral and dorsal prostates, and to the kidneys, were measured using the radioactive microsphere technique. In the bicalutamide experiments, some rats were treated with the Leydig cell toxin ethane dimethane sulphonate (EDS), to obtain a castration-like effect, and one group of these rats received testosterone. RESULTS: Finasteride induced a clear decrease in blood flow to the ventral and dorsal prostates after 7 days of treatment, with no significant changes in blood pressure or kidney blood flow. Bicalutamide inhibited the testosterone-induced increment of prostatic blood flow observed in EDS-treated animals. CONCLUSIONS: Finasteride, a blocker of 5alpha-reductase, decreases prostate blood flow after 7 days of administration. The response was slower than that after castration, but was of similar magnitude. Blood flow was also decreased after treatment with the androgen-receptor inhibitor bicalutamide. These observations suggest that prostatic blood flow is increased by dihydrotestosterone, and that the androgen receptor is responsible for mediating this effect.
Authors:
E Lekås; A Bergh; J E Damber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJU international     Volume:  85     ISSN:  1464-4096     ISO Abbreviation:  BJU Int.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  962-5     Citation Subset:  IM    
Affiliation:
Departments of Urology & Andrology, and Pathology, Umeå University Hospital, Umeå, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Androgen Antagonists / therapeutic use*
Anilides / therapeutic use*
Animals
Enzyme Inhibitors / therapeutic use*
Finasteride / therapeutic use*
Male
Nitriles
Organ Size / drug effects
Prostate / blood supply*
Prostatic Diseases / drug therapy*,  pathology
Rats
Rats, Sprague-Dawley
Regional Blood Flow / drug effects
Tosyl Compounds
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 0/Anilides; 0/Enzyme Inhibitors; 0/Nitriles; 0/Tosyl Compounds; 90357-06-5/bicalutamide; 98319-26-7/Finasteride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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