| Effects of fibrous and non-fibrous dusts on Chinese hamster V79 cells: Cytotoxicity or cytostasis? | |
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MedLine Citation:
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PMID: 20647069 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Chinese hamster V79 (CHV79) cells cultured in vitro were used to study the cytopathic effects of seven mineral dusts (four of which were fibrous). Lactate dehydrogenase release and the incorporation of [(3)H]thymidine into DNA were used to study toxic and static interactions, respectively. Crystalline silica dusts had a toxic effect on the cells. In contrast, Canadian chrysotile (chrysotile 'B') was relatively non-toxic but principally had a static effect upon CHV79 cells. Amphibole asbestos dusts demonstrated mainly static properties, albeit less marked than with chrysotile, and some toxic properties. Titanium dioxide was neither toxic nor static in vitro. |
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Authors:
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S O Lock; J Rockley; M Chamberlain; J V Friend |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology in vitro : an international journal published in association with BIBRA Volume: 1 ISSN: 0887-2333 ISO Abbreviation: Toxicol In Vitro Publication Date: 1987 |
Date Detail:
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Created Date: 2010-07-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712158 Medline TA: Toxicol In Vitro Country: England |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: - |
Copyright Information:
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Copyright © 1987. Published by Elsevier Ltd. |
Affiliation:
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Environmental Safety Laboratory, Unilever Research & Engineering, Colworth House, Sharnbrook, Bedford MK44 1LQ, England. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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