| Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA). | |
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MedLine Citation:
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PMID: 12775138 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effects of diphenhydramine 50 mg and fexofenadine 180 mg on cognitive performance using the Test of Variables of Attention (TOVA), and to ascertain whether the TOVA was sufficiently sensitive to differentiate between the effects of these first- and second-generation H1-receptor antagonists on performance. STUDY DESIGN: The study used a double-blind, placebo-controlled, randomized, crossover design. Forty-two subjects completed four separate TOVA tests: at baseline and after administration of placebo, diphenhydramine 50 mg, and fexofenadine 180 mg. On each occasion, subjects rated subjective feelings of drowsiness on a visual analog scale (VAS) before taking the TOVA. RESULTS: Compared with placebo, diphenhydramine caused an increased response time (P = 0.0230) and more omission errors (P = 0.0398). Diphenhydramine was also associated with increased drowsiness VAS ratings (P = 0.0065) compared with placebo. Diphenhydramine caused significantly more commission errors than fexofenadine (P = 0.0354). Neither placebonor fexofenadine 180 mg caused significant changes in any TOVA or VAS measurements compared with baseline. Fexofenadine was not statistically different from placebo for any evaluation. CONCLUSIONS: The TOVA was sufficiently sensitive to differentiate between the central nervous system effects of fexofenadine and diphenhydramine. Fexofenadine 180 mg had no significant effect on the TOVA measures of performance or on self-reported drowsiness compared with placebo. In contrast, diphenhydramine 50 mg caused significant increases in omission errors and response time on the TOVA and increases in self-reported drowsiness compared with placebo [corrected]. |
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Authors:
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Lyndon Mansfield; Catherine Mendoza; Jaime Flores; Suzanne G Meeves |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 90 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-30 Completed Date: 2003-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 554-9 Citation Subset: IM |
Affiliation:
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El Paso Institute for Medical Research and Development, El Paso, Texas 79902, USA. immunman@pol.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Attention / drug effects Cognition / drug effects* Cross-Over Studies Diphenhydramine / pharmacology* Double-Blind Method Female Histamine H1 Antagonists / pharmacology* Humans Male Middle Aged Reaction Time / drug effects Sleep Stages / drug effects Terfenadine / analogs & derivatives*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 138452-21-8/fexofenadine; 50679-08-8/Terfenadine; 58-73-1/Diphenhydramine |
| Comments/Corrections | |
Erratum In:
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Ann Allergy Asthma Immunol. 2003 Aug;91(2):167 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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