Document Detail

Effects of fexofenadine, diphenhydramine, and placebo on performance of the test of variables of attention (TOVA).
MedLine Citation:
PMID:  12775138     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of diphenhydramine 50 mg and fexofenadine 180 mg on cognitive performance using the Test of Variables of Attention (TOVA), and to ascertain whether the TOVA was sufficiently sensitive to differentiate between the effects of these first- and second-generation H1-receptor antagonists on performance. STUDY DESIGN: The study used a double-blind, placebo-controlled, randomized, crossover design. Forty-two subjects completed four separate TOVA tests: at baseline and after administration of placebo, diphenhydramine 50 mg, and fexofenadine 180 mg. On each occasion, subjects rated subjective feelings of drowsiness on a visual analog scale (VAS) before taking the TOVA. RESULTS: Compared with placebo, diphenhydramine caused an increased response time (P = 0.0230) and more omission errors (P = 0.0398). Diphenhydramine was also associated with increased drowsiness VAS ratings (P = 0.0065) compared with placebo. Diphenhydramine caused significantly more commission errors than fexofenadine (P = 0.0354). Neither placebonor fexofenadine 180 mg caused significant changes in any TOVA or VAS measurements compared with baseline. Fexofenadine was not statistically different from placebo for any evaluation. CONCLUSIONS: The TOVA was sufficiently sensitive to differentiate between the central nervous system effects of fexofenadine and diphenhydramine. Fexofenadine 180 mg had no significant effect on the TOVA measures of performance or on self-reported drowsiness compared with placebo. In contrast, diphenhydramine 50 mg caused significant increases in omission errors and response time on the TOVA and increases in self-reported drowsiness compared with placebo [corrected].
Lyndon Mansfield; Catherine Mendoza; Jaime Flores; Suzanne G Meeves
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  90     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-30     Completed Date:  2003-06-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-9     Citation Subset:  IM    
El Paso Institute for Medical Research and Development, El Paso, Texas 79902, USA.
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MeSH Terms
Attention / drug effects
Cognition / drug effects*
Cross-Over Studies
Diphenhydramine / pharmacology*
Double-Blind Method
Histamine H1 Antagonists / pharmacology*
Middle Aged
Reaction Time / drug effects
Sleep Stages / drug effects
Terfenadine / analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/Histamine H1 Antagonists; 138452-21-8/fexofenadine; 50679-08-8/Terfenadine; 58-73-1/Diphenhydramine
Erratum In:
Ann Allergy Asthma Immunol. 2003 Aug;91(2):167

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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