| Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. | |
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MedLine Citation:
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PMID: 17959201 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a maternal fetal rat model, we investigated the behavioral and neurotoxic effects of fetal exposure to isoflurane. Pregnant rats at gestational day 21 were anesthetized with 1.3% isoflurane for 6h. Apoptosis was quantified in the hippocampus and cortex at 2 and 18h after exposure in the fetal brain and in the postnatal day 5 (P5) pup brain. Spatial memory and learning of the fetal exposed pups were examined with the Morris Water Maze at juvenile and adult ages. Rat fetal exposure to isoflurane at pregnancy day 21 through maternal anesthesia significantly decreased spontaneous apoptosis in the hippocampal CA1 region and in the retrosplenial cortex at 2h after exposure, but not at 18h or at P5. Fetal exposure to isoflurane did not impair subsequent juvenile or adult postnatal spatial reference memory and learning and, in fact, improved spatial memory in the juvenile rat. These results show that isoflurane exposure during late pregnancy is not neurotoxic to the fetal brain and does not impair memory and learning in the juvenile or adult rat. |
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Authors:
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Yujuan Li; Ge Liang; Shouping Wang; Qingcheng Meng; Qiujun Wang; Huafeng Wei |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-09-20 |
Journal Detail:
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Title: Neuropharmacology Volume: 53 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-26 Completed Date: 2008-03-21 Revised Date: 2011-06-02 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
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Languages: eng Pagination: 942-50 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care, University of Pennsylvania, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anesthetics, Inhalation / adverse effects*, metabolism Animals Animals, Newborn Apoptosis / drug effects Behavior, Animal / drug effects Caspase 3 / metabolism DNA Fragmentation / drug effects Embryo, Mammalian Female Hippocampus / pathology In Situ Nick-End Labeling Isoflurane / adverse effects*, metabolism Maze Learning / drug effects* Memory / drug effects* Neurons / drug effects Pregnancy Prenatal Exposure Delayed Effects / pathology, physiopathology* Rats Space Perception / drug effects* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1-K08-GM-073224-01/GM/NIGMS NIH HHS; K08 GM073224-01/GM/NIGMS NIH HHS; K08 GM073224-02/GM/NIGMS NIH HHS; K08 GM073224-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; EC 3.4.22.-/Caspase 3 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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