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Effects of fermented brown rice on the intestinal environments in healthy adult.
MedLine Citation:
PMID:  21921425     Owner:  NLM     Status:  In-Data-Review    
The aim of this study is to investigate the prebiotic effects of brown rice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro and in healthy adults. Methods: Fresh fecal slurries from six healthy adults were incubated with FBRA to confirm prebiotic potentials of FBRA. Another thirty-six healthy adults were randomly allocated to 2 groups for the clinical study. Subjects consumed 21.0 g/day of either FBRA or control food for 2 weeks, followed by a 12-week intermission and then 2-week ingestion vice versa. Main outcome measures were bifidobacterial numbers and organic acid concentration in feces. Sub outcome measures were fecal microbiota, fecal environments and bowel function. Results: Incubation of fecal slurries with FBRA in vitro resulted in increased organic acids with individual-specific patterns. Bifidobacterial numbers were increased during incubation. In the clinical study, all participants safely completed this study. FBRA had little effect on fecal number of bifidobacteria, concentrations of organic acids or putrefactive metabolites, fecal pH, or fecal microbiota. Conclusion: FBRA has the potentials as a prebiotic, however, we could not detect its effects on the intestinal environment in vivo. The results in a clinical study indicated that FBRA could be safely used for healthy adults. J. Med. Invest. 58: 235-245, August, 2011.
Hideyuki Nemoto; Kazue Ikata; Hideki Arimochi; Teruaki Iwasaki; Yoshinari Ohnishi; Tomomi Kuwahara; Keiko Kataoka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  58     ISSN:  1349-6867     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-09-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  235-45     Citation Subset:  IM    
Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima.
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