| Effects of a fenugreek seed extract on feeding behaviour in the rat: metabolic-endocrine correlates. | |
| | |
MedLine Citation:
|
PMID: 8327543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fenugreek seeds (Trigonella foenum graecum L.) are assumed to have restorative and nutritive properties. The present work was designed to investigate the effects of a fenugreek seed extract on feeding behaviour. Experiments were performed to determine food consumption and motivation to eat as well as metabolic-endocrine changes in chronically treated animals. Male Wistar rats were given the seed extract orally (10 and 100 mg/day per 300 g body weight), mixed together with food, and control animals were monitored in parallel. The results show that chronic oral administration of the fenugreek extract significantly increases food intake and the motivation to eat. The treatment, however, does not prevent the anorexia nor the decreased motivation to eat induced by d-fenfluramine (2 mg/kg, IP). An increase in plasma insulin and a decrease in total cholesterol and very low-density lipoprotein (VLDL)-low-density lipoprotein (LDL) total cholesterol were also observed. In conclusion, chronic administration of a fenugreek seed extract enhances food consumption and motivation to eat in rats and also induces hyperinsulinemia as well as hypocholesterolemia. |
| | |
Authors:
|
P Petit; Y Sauvaire; G Ponsin; M Manteghetti; A Fave; G Ribes |
Related Documents
:
|
16521113 - Evaluation of the antioxidant activity of wheatgrass (triticum aestivum l.) as a functi... 11714333 - Analysis of glycosidically bound aroma precursors in tea leaves. 3. change in the glyco... 8883103 - Molecular mechanisms of olfactory processing in the mammalian olfactory epithelium. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 45 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1993 Jun |
Date Detail:
|
Created Date: 1993-08-11 Completed Date: 1993-08-11 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 369-74 Citation Subset: IM |
Affiliation:
|
Laboratoire de Pharmacologie, CNRS URA 599, Faculté de Médecine, Montpellier, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anorexia / chemically induced, drug therapy Cholesterol / blood Drinking / drug effects Eating / drug effects Fabaceae Feeding Behavior / drug effects*, physiology Insulin / blood Male Motivation Plant Extracts / pharmacology* Plants, Medicinal Rats Rats, Wistar Seeds Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Plant Extracts; 11061-68-0/Insulin; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rapid eye movement sleep deprivation increases chloride-sensitive Mg-ATPase activity in the rat brai...
Next Document: Chronic and acute tolerance to subjective effects of nicotine.