| Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants. | |
| | |
MedLine Citation:
|
PMID: 20466334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mg/kg dexmedetomidine (Group D, n = 30) or 2 mg/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine-lidocaine-propofol combination than with the fentanyl-lidocaine-propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine. |
| | |
Authors:
|
Volkan Hanci; Gülay Erdoğan; Rahşan Dilek Okyay; Bülent Serhan Yurtlu; Hilal Ayoğlu; Yunus Baydilek; Işil Ozkoçak Turan |
Related Documents
:
|
7772424 - Prophylactic i.m. ephedrine in bupivacaine spinal anaesthesia. 8572354 - Prediction of movement during propofol/nitrous oxide anesthesia. performance of concent... 16394684 - Maternal and neonatal effects of remifentanil at induction of general anesthesia for ce... 16261464 - Landiolol attenuates the cardiovascular response to tracheal intubation. 2957554 - Cardiac involvement in essential hypertension. prevalence, pathophysiology, and prognos... 20829634 - Delayed onset of cardiac compressions in cardiopulmonary resuscitation of newborn pigs ... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Kaohsiung journal of medical sciences Volume: 26 ISSN: 1607-551X ISO Abbreviation: Kaohsiung J. Med. Sci. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-14 Completed Date: 2010-08-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960562 Medline TA: Kaohsiung J Med Sci Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 244-50 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Anesthesiology and Reanimation, School of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. vhanci@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Anesthetics, Intravenous / administration & dosage*, adverse effects Blood Pressure / drug effects Dexmedetomidine / administration & dosage*, adverse effects Drug Combinations Female Fentanyl / administration & dosage*, adverse effects Heart Rate / drug effects Humans Intubation, Intratracheal* Lidocaine / administration & dosage*, adverse effects Male Middle Aged Propofol / administration & dosage*, adverse effects Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Intravenous; 0/Drug Combinations; 113775-47-6/Dexmedetomidine; 137-58-6/Lidocaine; 2078-54-8/Propofol; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blood loss after minimally invasive total knee arthroplasty: effects of imageless navigation.
Next Document: Effect of memantine on overactive detrusor in rats with spinal cord injury.