Document Detail


Effects of fenoterol on ventilatory responses to hypoxia and hypercapnia in normal subjects.
MedLine Citation:
PMID:  7701451     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The effects of beta 2 adrenergic agonists on chemoreceptors remain controversial. This study was designed to examine whether fenoterol, a beta 2 adrenergic agonist, increases the ventilatory responses to hypercapnia (HCVR) and hypoxia (HVR) in normal subjects. METHODS: HCVR was tested with a rebreathing method and HVR was examined with a progressive isocapnic hypoxic method in 11 normal subjects. Both HCVR and HVR were assessed by the slope of occlusion pressure (P0.1) or ventilation (VE) plotted against end tidal carbon dioxide pressure and arterial oxygen saturation, respectively. Respiratory muscle strength, spirometric values and lung volume were measured. After a single oral administration of 5 mg fenoterol or placebo HCVR and HVR were evaluated. RESULTS: Fenoterol treatment did not change the specific airway conductance or forced expiratory volume in one second. Respiratory muscle strength did not change. Fenoterol increased the slope of the HCVR of both P0.1 (from 0.251 (0.116) to 0.386 (0.206) kPa/kPa, average increase 71%) and VE (from 10.7 (3.4) to 15.1 (4.2) l/min/kPa, average increase 52%), and shifted the response curves to higher values. For the HVR fenoterol increased the slopes of both P0.1 and VE (from -4.06 (2.00) x 10(-3) to -7.99 (4.29) x 10(-3) kPa/%, an average increase of 83%, and from -0.221 (0.070) to -0.313 (0.112) l/min/%, a 44.5% increase, respectively), and shifted the response curves to higher values. CONCLUSION: Acute administration of fenoterol increases the ventilatory responses to both hypercapnia and hypoxia in normal subjects.
Authors:
Y Yoshiike; S Suzuki; Y Watanuki; T Okubo
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  50     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM; S    
Affiliation:
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology*
Double-Blind Method
Fenoterol / pharmacology*
Humans
Hypercapnia / physiopathology*
Male
Middle Aged
Random Allocation
Respiration / drug effects*
Chemical
Reg. No./Substance:
13392-18-2/Fenoterol
Comments/Corrections

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