| Effects of female sex hormones on caffeine-induced epileptiform activity in rats. | |
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MedLine Citation:
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PMID: 20063987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Research on female sex hormones has demonstrated that estrogen aggravates epileptogenesis. Theoretically, this means that the frequency of epileptic attacks should be decreased in epileptic women during menopause. However, although epilepsy attacks are reported to decrease in some women during menopause, they may not change in others. Increases in attack frequency have even been reported during menopause in some epileptic women. This study has investigated the effects of estrogen, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) on caffeine-induced epileptiform activity in rats. Estrogen was found to increase epileptiform activity in a dose-dependent manner via its own receptors. In contrast, progesterone had no effect on epileptiform activity. FSH and LH suppressed epileptiform activity at low doses; however, at high doses they enhanced it. In conclusion, we suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH. |
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Authors:
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Bunyamin Borekci; Metin Ingec; Mehmet Yilmaz; Osman Kukula; Mehmet Karaca; Ahmet Hacimuftuoglu; Zekai Halici; Halis Suleyman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-14 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, Department of Obstetrics and Gynecology, Atatürk University, Erzurum, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caffeine / diagnostic use* Corticosterone / blood Epilepsy / chemically induced*, prevention & control* Epinephrine / blood Estrogen Antagonists / administration & dosage Estrogens / administration & dosage, physiology Female Follicle Stimulating Hormone / administration & dosage Gonadal Steroid Hormones / administration & dosage* Luteinizing Hormone / administration & dosage Norepinephrine / blood Ovariectomy Progesterone / administration & dosage Rats Rats, Wistar Tamoxifen / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Antagonists; 0/Estrogens; 0/Gonadal Steroid Hormones; 10540-29-1/Tamoxifen; 50-22-6/Corticosterone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-83-0/Progesterone; 58-08-2/Caffeine; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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