Document Detail

Effects of female sex hormones on caffeine-induced epileptiform activity in rats.
MedLine Citation:
PMID:  20063987     Owner:  NLM     Status:  MEDLINE    
Research on female sex hormones has demonstrated that estrogen aggravates epileptogenesis. Theoretically, this means that the frequency of epileptic attacks should be decreased in epileptic women during menopause. However, although epilepsy attacks are reported to decrease in some women during menopause, they may not change in others. Increases in attack frequency have even been reported during menopause in some epileptic women. This study has investigated the effects of estrogen, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) on caffeine-induced epileptiform activity in rats. Estrogen was found to increase epileptiform activity in a dose-dependent manner via its own receptors. In contrast, progesterone had no effect on epileptiform activity. FSH and LH suppressed epileptiform activity at low doses; however, at high doses they enhanced it. In conclusion, we suggest that the occurrence or aggravation of epilepsy, despite estrogen deficiency in the menopausal or post-menopausal period, is related to excessive accumulation of FSH and LH.
Bunyamin Borekci; Metin Ingec; Mehmet Yilmaz; Osman Kukula; Mehmet Karaca; Ahmet Hacimuftuoglu; Zekai Halici; Halis Suleyman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
Faculty of Medicine, Department of Obstetrics and Gynecology, Atatürk University, Erzurum, Turkey.
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MeSH Terms
Caffeine / diagnostic use*
Corticosterone / blood
Epilepsy / chemically induced*,  prevention & control*
Epinephrine / blood
Estrogen Antagonists / administration & dosage
Estrogens / administration & dosage,  physiology
Follicle Stimulating Hormone / administration & dosage
Gonadal Steroid Hormones / administration & dosage*
Luteinizing Hormone / administration & dosage
Norepinephrine / blood
Progesterone / administration & dosage
Rats, Wistar
Tamoxifen / administration & dosage
Reg. No./Substance:
0/Estrogen Antagonists; 0/Estrogens; 0/Gonadal Steroid Hormones; 10540-29-1/Tamoxifen; 50-22-6/Corticosterone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 57-83-0/Progesterone; 58-08-2/Caffeine; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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