Document Detail

Effects of feeding L-carnitine to gilts through day 70 of gestation on litter traits and the expression of insulin-like growth factor system components and L-carnitine concentration in foetal tissues.
MedLine Citation:
PMID:  19012611     Owner:  NLM     Status:  MEDLINE    
We investigated the influence of supplemental L-carnitine on foetal blood metabolites, litter characteristics, L-carnitine concentration in skeletal muscle and insulin-like growth factor (IGF) axis components in foetal hepatic and skeletal muscle tissues at day 40, 55 and 70 of gestating gilts. A total of 59 gilts (body weight = 137.7 kg) received a constant feed allowance of 1.75 kg/day and a top-dress containing either 0 or 50 ppm of L-carnitine starting on the first day of breeding through the allotted gestation length. Foetuses from the gilts fed diets with L-carnitine tended to be heavier (p = 0.06) and the circulating IGF-II tended to be lower (p = 0.09) at day 70, compared with the foetuses from the control gilts. Insulin-like growth factor-I messenger RNA (mRNA) was lower (p = 0.05) in hepatic tissue in the foetuses collected from gilts fed L-carnitine. Free and total carnitine concentration increased (p < 0.05) in the skeletal muscle from the foetuses collected from gilts fed supplemental L-carnitine. This study showed that L-carnitine had beneficial effects on the average foetal weight at day 70 of gestation, associated with changes in the foetal IGF system.
K R Brown; R D Goodband; M D Tokach; S S Dritz; J L Nelssen; J E Minton; J J Higgins; X Lin; J Odle; J C Woodworth; B J Johnson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  92     ISSN:  1439-0396     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  660-7     Citation Subset:  IM    
Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS, USA.
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MeSH Terms
Animal Feed
Animal Nutritional Physiological Phenomena
Carnitine / administration & dosage*
Dietary Supplements
Fetal Development / drug effects*,  physiology
Gestational Age
Insulin-Like Growth Factor I / metabolism
Liver / metabolism
Muscle, Skeletal / metabolism
Pregnancy, Animal / blood,  metabolism*
RNA, Messenger / metabolism
Random Allocation
Somatomedins / metabolism*
Swine / blood,  growth & development,  metabolism,  physiology*
Reg. No./Substance:
0/RNA, Messenger; 0/Somatomedins; 541-15-1/Carnitine; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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