Document Detail


Effects of fatty acids on proliferation and activation of human synovial compartment lymphocytes.
MedLine Citation:
PMID:  7964169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The object of this study was to determine the effects of eicosanoid precursor fatty acids on activation and proliferation of T lymphocytes from synovial fluid and synovial tissue of rheumatoid arthritis patients. Proliferation was determined by direct cell counts; phenotypic characterization of surfaces molecules was by cytofluorometric analysis. Dihomogammalinolenic acid, arachidonic acid, and eicosapentaenoic acid suppressed proliferation of interleukin-2-dependent lymphocytes by as much as 80%; cell viability was not altered by fatty acids. Administration of particular fatty acids may prove to be a useful therapeutic intervention in rheumatoid arthritis patients because of their ability to suppress activation and proliferation of synovial compartment T lymphocytes.
Authors:
D M DeMarco; D Santoli; R B Zurier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  56     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-12     Completed Date:  1994-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  612-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Pennsylvania, Wistar Institute of Anatomy & Biology, Philadelphia.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / immunology*,  pathology
Cell Division / drug effects
Cells, Cultured
Eicosanoic Acids / pharmacology*
Humans
Interleukin-2 / pharmacology
Lymphocyte Activation / drug effects*
Synovial Fluid / cytology*
Synovial Membrane / pathology*
T-Lymphocyte Subsets / drug effects*,  pathology
Grant Support
ID/Acronym/Agency:
AR-38501/AR/NIAMS NIH HHS; CA 47589/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Eicosanoic Acids; 0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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