| Effects of fatty acid esters of cheno- and ursodeoxycholic acids on gallstone formation in hamsters. | |
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MedLine Citation:
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PMID: 3797448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fatty acid esters (at the 7 position) of chenodeoxycholic (CDCA) and ursodeoxycholic (UDCA) acids have been tested for their effects on formation and dissolution of gallstones in hamsters. The free bile acids were fed at a level of 0.2% of the diet and esters were fed at equimolar levels. The earlier finding that CDCA does not affect gallstone formation in hamsters fed the Dam and Christensen diet were confirmed. The acetic, butyric and lauric acid esters of CDCA had a very slight inhibitory effect on lithogenesis but CDCA 7 oleate and linoleate completely inhibited gallstone formation. UDCA and its 7 oleate inhibited both formation and progression of gallstones. The observed effects are probably a function of the form of the bile acid and not of the esterifying acid. The observation that ethyl oleate has a slight litholytic effect suggests that the acid moiety of the ester may exert a slight influence. |
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Authors:
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D Kritchevsky; D M Klurfeld; C Sirtori |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacological research communications Volume: 18 ISSN: 0031-6989 ISO Abbreviation: Pharmacol Res Commun Publication Date: 1986 Nov |
Date Detail:
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Created Date: 1987-02-10 Completed Date: 1987-02-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0236354 Medline TA: Pharmacol Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 997-1002 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chenodeoxycholic Acid / analogs & derivatives*, pharmacology Cholelithiasis / prevention & control* Cricetinae Deoxycholic Acid / analogs & derivatives* Esters / pharmacology Mesocricetus Oleic Acids / pharmacology Ursodeoxycholic Acid / analogs & derivatives*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL-00734/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Esters; 0/Oleic Acids; 111-62-6/ethyl oleate; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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