Document Detail


Effects of fatty acid esters of cheno- and ursodeoxycholic acids on gallstone formation in hamsters.
MedLine Citation:
PMID:  3797448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fatty acid esters (at the 7 position) of chenodeoxycholic (CDCA) and ursodeoxycholic (UDCA) acids have been tested for their effects on formation and dissolution of gallstones in hamsters. The free bile acids were fed at a level of 0.2% of the diet and esters were fed at equimolar levels. The earlier finding that CDCA does not affect gallstone formation in hamsters fed the Dam and Christensen diet were confirmed. The acetic, butyric and lauric acid esters of CDCA had a very slight inhibitory effect on lithogenesis but CDCA 7 oleate and linoleate completely inhibited gallstone formation. UDCA and its 7 oleate inhibited both formation and progression of gallstones. The observed effects are probably a function of the form of the bile acid and not of the esterifying acid. The observation that ethyl oleate has a slight litholytic effect suggests that the acid moiety of the ester may exert a slight influence.
Authors:
D Kritchevsky; D M Klurfeld; C Sirtori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacological research communications     Volume:  18     ISSN:  0031-6989     ISO Abbreviation:  Pharmacol Res Commun     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-02-10     Completed Date:  1987-02-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0236354     Medline TA:  Pharmacol Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  997-1002     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chenodeoxycholic Acid / analogs & derivatives*,  pharmacology
Cholelithiasis / prevention & control*
Cricetinae
Deoxycholic Acid / analogs & derivatives*
Esters / pharmacology
Mesocricetus
Oleic Acids / pharmacology
Ursodeoxycholic Acid / analogs & derivatives*,  pharmacology
Grant Support
ID/Acronym/Agency:
HL-00734/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Esters; 0/Oleic Acids; 111-62-6/ethyl oleate; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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