Document Detail


Effects of falipamil (AQ-A 39) on heart rate and blood pressure in resting and exercising healthy volunteers.
MedLine Citation:
PMID:  2475699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Falipamil (AQ-A 39) is a new verapamil derivative which exerts antitachycardic effects by a direct action on the sinus node. Its effects on heart rate (HR), blood pressure (BP) and ECG intervals were studied in 12 healthy volunteers, at rest and during bicycle exercise tests. In a double-blind, cross-over, single-dose study, the effects of falipamil (100 and 200 mg) during 8-h post-dosing were compared with those of placebo. Falipamil did not modify resting HR, BP, and electrocardiogram (ECG) intervals significantly. Maximal exercise HR significantly decreased by 5.3 +/- 2.9 (SD)% and 11.2 +/- 3.6% 2 h after the 100- and 200-mg dose respectively, whereas placebo had no effect. Exercise BP was not significantly modified by falipamil. The slopes of HR-workload relationships significantly decreased with falipamil. Peak plasma concentrations of falipamil occurred 1-1.5 h after absorption, and the falipamil-induced decrease in exercise HR over 8 h postdosing was proportional to falipamil plasma concentrations. These results suggest that falipamil decreases HR at exercise in normal subjects and may exert antianginal effects in patients with myocardial ischemia.
Authors:
M Naudascher; P Jaillon; B Lecocq; V Lecocq; A Ferry; J Hilaire; J F Maria
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  14     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-04     Completed Date:  1989-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Unité de Pharmacologie Clinique, Hôpital Saint-Antoine, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Cardiovascular Agents / adverse effects,  pharmacokinetics,  pharmacology*
Double-Blind Method
Exercise*
Heart Rate / drug effects*
Humans
Isoindoles
Male
Phthalimides / adverse effects,  pharmacokinetics,  pharmacology*
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Isoindoles; 0/Phthalimides; 77862-92-1/falipamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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