Document Detail

Effects of extract from Clerodendron trichotomum on blood pressure and renal function in rats and dogs.
MedLine Citation:
PMID:  8072307     Owner:  NLM     Status:  MEDLINE    
Clerodendron trichotomum Thunb. is a herb which has been used for treatment of hypertension in Chinese medicine. To assess the action of the herb on blood pressure and renal function, the extract was administered to rats and dogs. Intravenous administration of the extract elicited renal vasodilation and increased urine flow and urinary sodium excretion. Acute oral administration of the extract reduced blood pressure of spontaneously hypertensive rats but not of normotensive control rats. Chronic daily administration for 6 weeks prevented the increase in blood pressure of spontaneously hypertensive rats. These results may give some support to the claim on the clinical efficacy of the extract of Clerodendron trichotomum Thunb.
G W Lu; K Miura; T Yukimura; K Yamamoto
Related Documents :
11728237 - Effects of wild versus cultivated garlic on blood pressure and other parameters in hype...
25406897 - Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs wit...
25477627 - Drying characteristics and quality of shiitake mushroom undergoing microwave-vacuum dry...
12218357 - A modified technique for tail cuff pressure measurement in unrestrained conscious rats.
20418477 - Preventing increased blood pressure in the obese zucker rat improves severity of stroke.
19024087 - Effect of inhalation of nebulized no donor substance on acute hypoxic lung injury in ne...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  42     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Pharmacology, Osaka City University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Blood Pressure / drug effects*
Drugs, Chinese Herbal / pharmacology*,  therapeutic use
Hypertension / drug therapy*
Injections, Intravenous
Kidney / drug effects*,  physiology
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Renal Circulation / drug effects
Species Specificity
Vascular Resistance / drug effects
Reg. No./Substance:
0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Traditional herbal remedies used for the treatment of urinary schistosomiasis in Zimbabwe.
Next Document:  Amrita Bindu--a salt-spice-herbal health food supplement for the prevention of nitrosamine induced d...