Document Detail


Effects of extract from Clerodendron trichotomum on blood pressure and renal function in rats and dogs.
MedLine Citation:
PMID:  8072307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clerodendron trichotomum Thunb. is a herb which has been used for treatment of hypertension in Chinese medicine. To assess the action of the herb on blood pressure and renal function, the extract was administered to rats and dogs. Intravenous administration of the extract elicited renal vasodilation and increased urine flow and urinary sodium excretion. Acute oral administration of the extract reduced blood pressure of spontaneously hypertensive rats but not of normotensive control rats. Chronic daily administration for 6 weeks prevented the increase in blood pressure of spontaneously hypertensive rats. These results may give some support to the claim on the clinical efficacy of the extract of Clerodendron trichotomum Thunb.
Authors:
G W Lu; K Miura; T Yukimura; K Yamamoto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  42     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-23     Completed Date:  1994-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Osaka City University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Blood Pressure / drug effects*
Dogs
Drugs, Chinese Herbal / pharmacology*,  therapeutic use
Female
Hypertension / drug therapy*
Injections, Intravenous
Kidney / drug effects*,  physiology
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Renal Circulation / drug effects
Species Specificity
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Drugs, Chinese Herbal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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