Document Detail


Effects of extracorporeal shock wave lithotripsy to one kidney on bilateral glomerular filtration rate and PAH clearance in minipigs.
MedLine Citation:
PMID:  8808917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: This study examined the acute time course of effects of extracorporeal shock wave lithotripsy (ESWL) on renal hemodynamics in anesthetized minipigs with and without pretreatment with verapamil. MATERIALS AND METHODS: We applied ESWL (2000 shocks, 24 kV, unmodified Dornier HM3), to the right kidneys of isoflurane-anesthetized female pigs. Urine flow and renal hemodynamics were monitored from each kidney via ureteral balloon catheters. Arterial blood pressure and bilateral urine flow, glomerular filtration rate (GFR, insulin clearance) and renal plasma flow (RPF, para-aminohippurate clearance) were monitored for 45 minutes before ESWL, and at 1, 4 and 24 hours after ESWL. RESULTS: Treatment with ESWL consistently caused unilateral hematuria and subcapsular renal hematomas in the shocked kidneys and significantly reduced GFR and RPF in those kidneys at 1 and 4 hours after ESWL. Urine flow was reduced through 24 hours in the shocked kidneys. Renal plasma flow, but not GFR, was significantly reduced in the contralateral (unshocked) kidneys at 1 and 4 hours after ESWL to the other kidneys. Verapamil blunted the ESWL-induced reductions of urine flow, GFR and RPF in the shocked kidneys and eliminated the reduction of RPF in the unshocked kidneys. CONCLUSIONS: These experiments demonstrate that ESWL to 1 kidney acutely impaired hemodynamics in both kidneys and that verapamil attenuated the response in the shocked kidneys and eliminated it in the contralateral unshocked kidneys.
Authors:
L R Willis; A P Evan; B A Connors; G Reed; N S Fineberg; J A Lingeman
Related Documents :
25472857 - Relocation of cryopreserved umbilical cord blood samples using a high-capacity dry ship...
4686027 - Maturation of glomerular blood flow distribution in the new-born dog.
1515347 - Longitudinal studies of exposure to cadmium.
1129297 - Effect of blood volume expansion on tubule sodium transport in the isolated dog kidney.
19871657 - Absorption from the pulmonary alveoli.
25433297 - Normobaric hyperoxia alters the microcirculation in healthy volunteers.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  156     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-07     Completed Date:  1996-11-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1502-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202-5120, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channel Blockers / pharmacokinetics*
Female
Glomerular Filtration Rate / drug effects,  physiology*
Lithotripsy*
Renal Circulation / drug effects,  physiology
Swine
Swine, Miniature
Verapamil / pharmacology
p-Aminohippuric Acid / pharmacokinetics*
Grant Support
ID/Acronym/Agency:
P01-DK4388/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 52-53-9/Verapamil; 61-78-9/p-Aminohippuric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electromotive drug administration to the urinary bladder: an animal model and preliminary results.
Next Document:  Gracilis muscle dynamic urethral sphincter myoplasty: rat model experience.