Document Detail

Effects of extracorporeal shock wave lithotripsy on plasma concentrations of endothelin and renin in humans.
MedLine Citation:
PMID:  7490895     Owner:  NLM     Status:  MEDLINE    
PURPOSE: There is ongoing controversy regarding blood pressure changes after extracorporeal shock wave lithotripsy (ESWL*). Experimental data suggest a role for renin but only few data are relevant to humans. It has been shown that renin secretion is stimulated by endothelin, a recently discovered peptide with strong vasoconstrictive properties and stimulating effects on renin secretion. Endothelin is relevant in the development of hypertension and acute renal failure. MATERIALS AND METHODS: In a prospective study of 48 normotensive patients undergoing ESWL for renal stones the influence of high energy shock waves on plasma endothelin and active renin was analyzed. These substances are secreted by renal cells in response to hemodynamic alterations, and inflammatory and traumatic processes. Peripheral blood samples were analyzed for active renin and endothelin before, and immediately, 1, 3 and 5 days after ESWL. Blood pressure was measured before, and 1, 3 and 5 days after ESWL. RESULTS: Only a slight and transient increase was noted in active renin, which was in the same range as that found after mental stress. Endothelin and blood pressure were not significantly influenced by ESWL. There was no correlation between endothelin and active renin. Thus, the increase in active renin was not mediated by endothelin. CONCLUSIONS: The transient increase in active renin cannot be attributed to the development of hypertension. The lack of influence of ESWL on endothelin indicates that ESWL, at least in the routine clinical setting, does not cause severe renal trauma.
W L Strohmaier; A M Carl; D M Wilbert; K H Bichler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  155     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-51     Citation Subset:  AIM; IM    
Department of Urology, Eberhard-Karls-University, Tuebingen, Germany.
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MeSH Terms
Blood Pressure / physiology
Endothelins / blood*
Hypertension / etiology
Kidney Calculi / blood,  physiopathology,  therapy*
Lithotripsy* / adverse effects
Middle Aged
Prospective Studies
Renin / blood*
Reg. No./Substance:
0/Endothelins; EC
Comment In:
J Urol. 1996 Jan;155(1):56-7   [PMID:  7490897 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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