| Effects of extracellular matrices derived from different cell sources on chondrocyte functions. | |
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MedLine Citation:
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PMID: 21509950 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cell-derived extracellular matrices (ECMs) are a key factor in regulating cell functions in tissue engineering and regenerative medicine. The fact that cells are surrounded by their specific ECM in vivo elicits the need to elucidate the effects of ECM derived from different cell sources on cell functions. Here, three types of ECM were prepared by decellularizing cultured chondrocytes, fibroblasts, and mesenchymal stem cells (MSC) and used for chondrocyte culture to compare their effects on chondrocyte adhesion, proliferation, and differentiation. Chondrocyte adhesion to the chondrocyte-derived ECM was greater than those to the fibroblast- and MSC-derived ECM. Chondrocyte proliferation on the chondrocyte-derived ECM was lower than those on the fibroblast- and MSC-derived ECM. The ECM showed no evident effect on chondrocyte differentiation. The effects of ECM on cell functions depended on the cell source used to prepare the ECM. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011. |
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Authors:
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Takashi Hoshiba; Hongxu Lu; Tomoe Yamada; Naoki Kawazoe; Tetsuya Tateishi; Guoping Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-22 |
Journal Detail:
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Title: Biotechnology progress Volume: - ISSN: 1520-6033 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506292 Medline TA: Biotechnol Prog Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 American Institute of Chemical Engineers (AIChE). |
Affiliation:
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Biomaterials Center, National Institute for Materials Science, Tsukuba 305-0044, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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