Document Detail


Effects of an extra X chromosome on language lateralization: an fMRI study with Klinefelter men (47,XXY).
MedLine Citation:
PMID:  18372164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
De novo occurring genetic variations provide an opportunity to study the effects of genes on structure and function of the brain. The presence of an extra X chromosome in men (XXY karyotype) has been associated with language deficits. Recently, schizophrenia spectrum traits have been observed in XXY men, which is of interest as language deficits are prominent in schizophrenia. One possible neural mechanism underlying these deficits is reduced hemispheric specialization for language. However, there has been no study of brain activity patterns during language processing in XXY men. Also, it remains unclear whether reduced language lateralization may be related to mental functioning in these men. We used functional Magnetic Resonance Imaging (fMRI) to study language lateralization in 15 XXY men as compared to 14 control men. We used a psychiatric interview and a schizotypy questionnaire to explore the relation between language lateralization and mental functioning in these men, with special interest in disorganization of thought and language. Compared to controls, the XXY group showed reduced hemispheric specialization for language, which was due to decreased functional asymmetry in the superior temporal gyrus (STG) and the supramarginal gyrus (part of Wernicke's area). Reduced lateralization in the STG correlated significantly with disorganization traits. These findings suggest the X chromosome may be involved in hemispheric specialization for language. Moreover, reduced hemispheric specialization for language processing in the superior temporal gyrus may have important consequences for mental functioning, as it was associated with disorganization of thought and language as seen in the schizophrenia spectrum.
Authors:
Sophie van Rijn; André Aleman; Hanna Swaab; Matthijs Vink; Iris Sommer; René S Kahn
Related Documents :
11378844 - Affected sibling pair linkage analysis of qualitative and quantitative traits for schiz...
16959794 - Impact of the disc1 ser704cys polymorphism on risk for major depression, brain morpholo...
19102774 - Dna methylation and mrna expression of syn iii, a candidate gene for schizophrenia.
15784724 - The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility...
11069104 - Melanesian origin of polynesian y chromosomes.
21619714 - Characterisation of a novel paralog of scavenger receptor class b member i (scarb1) in ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-26
Journal Detail:
Title:  Schizophrenia research     Volume:  101     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-08-13     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-25     Citation Subset:  IM    
Affiliation:
Utrecht University, Helmholtz Institute, Department of Experimental Psychology, Heidelberglaan 2, 3584 CS, Utrecht, The Netherlands. srijn@fsw.leidenuniv.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain / blood supply*,  physiopathology
Brain Mapping
Chromosomes, Human, X*
Functional Laterality / physiology*
Humans
Image Processing, Computer-Assisted
Klinefelter Syndrome* / genetics,  pathology,  physiopathology
Language*
Magnetic Resonance Imaging*
Male
Middle Aged
Oxygen / blood
Personality Inventory
Schizophrenic Psychology
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall).
Next Document:  Molecular and clinical characterization in Japanese and Korean patients with Hailey-Hailey disease: ...