Document Detail


Effects of an external nasal strip and frusemide on pulmonary haemorrhage in Thoroughbreds following high-intensity exercise.
MedLine Citation:
PMID:  11720029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to examine the effects of an external nasal strip (NS), frusemide (FR) and a combination of the 2 treatments (NS + FR) on exercise-induced pulmonary haemorrhage (EIPH) in Thoroughbred horses. It was hypothesised that both the NS and FR would attenuate EIPH as assessed by red blood cell count in bronchoalveolar lavage fluid. In random order, 8 horses completed each of 4 sprint exercise tests on a treadmill: 1) NS; 2) FR (0.5 mg/kg bwt i.v., 4 h pre-exercise); 3) NS + FR; and 4) control (C; no treatment). After a 5 min warm-up (4.5 m/s), horses completed 2 min running at 120% maximum oxygen consumption (VO2max) with the treadmill set at 3 degrees incline. Mean +/- s.d. running speed was 14.2+/-0.2 m/s. In the FR and NS + FR trials, horses carried weight equal to that lost as a result of frusemide administration. During exercise at 120% Vo2max, oxygen consumption (Vo2) and carbon dioxide production (Vco2) were measured at 15 s intervals. Plasma lactate concentration was measured in samples collected before exercise, at the end of the sprint and after 5 min cool-down at the trot. Thirty minutes after the run, bronchoalveolar lavage (BAL) was performed and the red cell count in the fluid quantified. Vo2 and Vco2 were significantly lower in NS and NS + FR trials than in the C and FR trials at the end of the sprint exercise protocol. However, plasma lactate concentrations did not differ among treatments. Compared with the C trial (61.1+/-30.5 x 10(6) red blood cells/ml BAL fluid), pulmonary haemorrhage was significantly (P<0.05) decreased in both the NS (15.9+/-4.0 x 106 RBC/ml) and FR (12.2+/-5.8 x 10(6) RBC/ml) trials. EIPH in the NS + FR trial (7.9+/-1.0 x 10(6) RBC/ml) was further diminished (P<0.05) compared to the NS trial, but not different from the FR trial. We conclude that both the external nasal strip and frusemide attenuate pulmonary haemorrhage in Thoroughbred horses during high-speed sprint exercise. The external nasal strip appears to lower the metabolic cost of supramaximal exertion in horses. Given the purported ergogenic effects of frusemide, the external nasal strip is a valuable alternative for the attenuation of EIPH.
Authors:
R J Geor; L Ommundson; G Fenton; J D Pagan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal     Volume:  33     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-26     Completed Date:  2002-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  England    
Other Details:
Languages:  eng     Pagination:  577-84     Citation Subset:  IM    
Affiliation:
Kentucky Equine Research, Inc., Versailles 40383, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Bronchoalveolar Lavage Fluid / cytology
Carbon Dioxide / metabolism
Combined Modality Therapy
Diuretics / pharmacology,  therapeutic use*
Erythrocyte Count / veterinary
Exercise Test / veterinary
Female
Furosemide / pharmacology,  therapeutic use*
Hemorrhage / prevention & control,  veterinary*
Horse Diseases / prevention & control*
Horses
Lactates / blood
Lung Diseases / prevention & control,  veterinary*
Male
Oxygen Consumption / drug effects
Physical Conditioning, Animal / adverse effects*
Pulmonary Gas Exchange / drug effects
Random Allocation
Time Factors
Chemical
Reg. No./Substance:
0/Diuretics; 0/Lactates; 124-38-9/Carbon Dioxide; 54-31-9/Furosemide
Comments/Corrections
Comment In:
Equine Vet J. 2001 Nov;33(6):537-9   [PMID:  11720022 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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