Document Detail


Effects of exposure period and dose of diethylstilbestrol on pregnancy in rats.
MedLine Citation:
PMID:  19887736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate the effect of exposure period and dose of diethylstilbestrol (DES), which has strong estrogenic activity, on pregnancy in rats. All rats with observed vaginal plugs or sperm in vaginal smear tests after mating were divided into 3 groups: those fed a normal diet, a diet mixed with DES throughout pregnancy and a diet mixed with DES from day 13 of pregnancy. DES was mixed into the diet at 0.1, 1, 10 and 100 ppm. All bred rats fed the normal diet and 0.1 ppm DES from day 13 of pregnancy delivered pups, while none of the rats treated with 1-100 ppm DES during pregnancy and 100 ppm DES from day 13 of pregnancy delivered any pups. The number of male and female pups born decreased in rats treated with 10 ppm DES from day 13 of pregnancy. These results suggest that DES could affect pregnancy and that the exposure period and dose may result in sterility, abortion, poor fetal growth and reduced number of pups born.
Authors:
Hiroaki Kawaguchi; Noriaki Miyoshi; Yoko Miyamoto; Masakazu Souda; Yoshihisa Umekita; Nobuhiro Yasuda; Hiroki Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  71     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2009-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1309-15     Citation Subset:  IM    
Affiliation:
Department of Veterinary Experimental Animal Science, Kagoshima University, Korimoto, Kagoshima 890-0065, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diethylstilbestrol / administration & dosage*,  pharmacology*
Dose-Response Relationship, Drug
Drug Administration Schedule
Endocrine Disruptors / administration & dosage*,  pharmacology*
Environmental Pollutants
Female
Male
Pregnancy
Pregnancy, Animal / drug effects*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Endocrine Disruptors; 0/Environmental Pollutants; 56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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