| Effects of expiratory resistive load on respiratory motor output in conscious humans. | |
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MedLine Citation:
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PMID: 3121575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined, in five conscious human subjects, the steady-state effects of expiratory resistive loading (ERL; R = 8 cmH2O.l-1.s) on the time course of inspiratory and postinspiratory muscle activities (IA and PIA, respectively) and ventilatory pattern during quiet breathing. Driving pressure (DP) was calculated by means of a respiratory neuromechanical model (J. Appl. Physiol. 51: 963-989, 1981) that permitted the derivation, from tidal volume and flow, of the occlusion pressure equivalent (at functional residual capacity) of respiratory neural output throughout the breath. ERL caused a prolongation of both neural inspiratory duration (12.2 +/- 6.9% SD) and expiratory duration (25.0 +/- 10.1%) and an increase in the amplitude of DP (16.5 +/- 10.2%) without any changes in the waveshape of IA and in end-expiratory level. The relative time course of PIA was not altered by ERL. Minute ventilation was depressed (-6.75 +/- 2.88%) during ERL with little change in alveolar PCO2. The results indicate that pulmonary gas exchange may be improved during ERL through increased tidal volume as well as delayed expiratory lung emptying secondary to sustained PIA. |
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Authors:
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C S Poon; M Younes; C G Gallagher |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 63 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-01-27 Completed Date: 1988-01-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1837-45 Citation Subset: IM; S |
Affiliation:
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Department of Electrical and Electronics Engineering, North Dakota State University, Fargo 58105. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance* Breath Tests Carbon Dioxide / analysis, blood Female Humans Male Pressure Respiration* Respiratory Function Tests Respiratory Muscles / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-32030/HL/NHLBI NIH HHS; HL-39794/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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