Document Detail


Effects of experimental hypercapnia on hippocampal long-term potentiation in anesthetized rats.
MedLine Citation:
PMID:  10076902     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of hypercapnia, which has been reported to impair consciousness, on the long-term potentiation of the population spike in the CA1 pyramidal cell of the hippocampus in anesthetized rats were studied. Experimental hypercapnemia was induced by inspired 13% CO2 with 21% O2. Arterial blood gas analysis after 80 min inspired 13% CO2 showed pH 7.08+/-0.05, PCO2 = 104.09+/-12.86 mmHg, PO2 = 90.71+/-18.89 mmHg, BE -4.64+/-2.97 (mean +/- SD, n = 18). Inspired 13% CO2 reduced the amplitude of the population spike to 50% of the baseline. After delivery of tetanic stimulation (400 Hz, five bursts of eight pulses, inter-burst interval 1 s) population spike height was enhanced to pre-tetanic levels. Withdrawal of inspired CO2 unmasked an increase in population spike amplitude. These findings suggest that acute retention of carbon dioxide, which is designated as pure hypercapnemia without hypoxemia, may suppress hippocampal synaptic transmission but not its plasticity.
Authors:
Y Itoh; M Yoshioka; O Kemmotsu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  260     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM; S    
Affiliation:
Department of Anesthesiology, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Blood Gas Analysis
Electric Stimulation
Evoked Potentials / physiology
Hippocampus / physiopathology*
Hypercapnia / physiopathology*
Long-Term Potentiation / physiology*
Male
Pyramidal Cells / physiology
Rats
Rats, Wistar
Synaptic Transmission / physiology

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