| Effects of experimental hypercapnia on hippocampal long-term potentiation in anesthetized rats. | |
| | |
MedLine Citation:
|
PMID: 10076902 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of hypercapnia, which has been reported to impair consciousness, on the long-term potentiation of the population spike in the CA1 pyramidal cell of the hippocampus in anesthetized rats were studied. Experimental hypercapnemia was induced by inspired 13% CO2 with 21% O2. Arterial blood gas analysis after 80 min inspired 13% CO2 showed pH 7.08+/-0.05, PCO2 = 104.09+/-12.86 mmHg, PO2 = 90.71+/-18.89 mmHg, BE -4.64+/-2.97 (mean +/- SD, n = 18). Inspired 13% CO2 reduced the amplitude of the population spike to 50% of the baseline. After delivery of tetanic stimulation (400 Hz, five bursts of eight pulses, inter-burst interval 1 s) population spike height was enhanced to pre-tetanic levels. Withdrawal of inspired CO2 unmasked an increase in population spike amplitude. These findings suggest that acute retention of carbon dioxide, which is designated as pure hypercapnemia without hypoxemia, may suppress hippocampal synaptic transmission but not its plasticity. |
| | |
Authors:
|
Y Itoh; M Yoshioka; O Kemmotsu |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neuroscience letters Volume: 260 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1999 Feb |
Date Detail:
|
Created Date: 1999-05-17 Completed Date: 1999-05-17 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 201-3 Citation Subset: IM; S |
Affiliation:
|
Department of Anesthesiology, Hokkaido University School of Medicine, Sapporo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia Animals Blood Gas Analysis Electric Stimulation Evoked Potentials / physiology Hippocampus / physiopathology* Hypercapnia / physiopathology* Long-Term Potentiation / physiology* Male Pyramidal Cells / physiology Rats Rats, Wistar Synaptic Transmission / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-rele...
Next Document: Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from p...