| Effects of experimental changes in nasal airway pressure on mucosal output of plasma. | |
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MedLine Citation:
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PMID: 12752558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microvascular extravasation, lamina propria flooding and luminal entry of plasma are key features of airway inflammation. We have suggested that the extravasated plasma moves across the epithelial lining along hydrostatic pressure gradients. The present study, involving healthy subjects, tests this hypothesis by examining effects of experimentally applied negative and positive luminal pressures on nasal output of plasma at baseline and at histamine-induced plasma exudation. The negative (-10 cmH2O) and positive (10 cmH2O) pressures were applied for 10 min after nasal spray administrations of diluent (saline) and histamine (0.5 mg). The mucosa was then lavaged and the lavage fluid levels of alpha2-macroglobulin were measured as index of plasma exudation. Nasal administrations of diluent and histamine (0.5 mg) were also carried out without any pressure applications. Histamine produced significant mucosal exudation of plasma. The negative luminal pressure augmented this response significantly as well as the baseline appearance of alpha2-macroglobulin in mucosal surface liquids. We conclude that extravasated plasma may be moved across the epithelium by a hydrostatic pressure-operated epithelial mechanism. |
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Authors:
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Søren Berg; Per Wollmer; Morgan Andersson; Carl G A Persson; Lennart Greiff |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 23 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-19 Completed Date: 2004-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 155-8 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, University Hospital, Lund, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exudates and Transudates / drug effects, immunology, metabolism* Histamine / diagnostic use Humans Nasal Lavage Fluid / chemistry* Nasal Mucosa / drug effects, immunology, metabolism* Nasal Provocation Tests / methods Plasma / metabolism* Positive-Pressure Respiration / methods* alpha-Macroglobulins / metabolism, secretion* |
| Chemical | |
Reg. No./Substance:
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0/alpha-Macroglobulins; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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