| Effects of exogenous vitamin C on ethanol toxicity in rats. | |
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MedLine Citation:
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PMID: 11214494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a mega dose of ascorbic acid (200 mg/100 g body wt.) on alcohol-induced toxicity in rats was evaluated. In rats administered alcohol and ascorbic acid, malondialdehyde (MDA), hydroperoxide and conjugated dienes decreased in comparison with that given alcohol alone. The reduced activities of scavenging enzymes, e.g. superoxide dismutase (SOD) and catalase, in ethanol-administered rats were also enhanced by the co-administration of ascorbic acid and ethanol. Co-administration of ethanol and ascorbic acid reduced phospholipids and MDA levels of the erythrocyte membrane in comparison with that of the ethanol fed rats. The reduction in the activities of glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamaglutamyl transpeptidase (GGT) and the decrease in triglycerides levels also clearly showed the protective action of ascorbic acid in reducing ethanol induced toxicity. |
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Authors:
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M V Suresh; B Menon; M Indira |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of physiology and pharmacology Volume: 44 ISSN: 0019-5499 ISO Abbreviation: Indian J. Physiol. Pharmacol. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-02-14 Completed Date: 2001-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374707 Medline TA: Indian J Physiol Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 401-10 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Kerala, Thiruvananthapuram-695 001. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Ascorbic Acid / blood, pharmacology* Catalase / drug effects, metabolism Central Nervous System Depressants / toxicity* Cholesterol / blood Ethanol / toxicity* Fatty Acids, Nonesterified Glutathione / drug effects, metabolism Lipid Peroxidation / drug effects*, physiology Male Malondialdehyde / blood Phospholipids / blood Rats Rats, Sprague-Dawley Superoxide Dismutase / metabolism Triglycerides / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Central Nervous System Depressants; 0/Fatty Acids, Nonesterified; 0/Phospholipids; 0/Triglycerides; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 64-17-5/Ethanol; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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