Document Detail


Effects of exogenous vitamin C on ethanol toxicity in rats.
MedLine Citation:
PMID:  11214494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a mega dose of ascorbic acid (200 mg/100 g body wt.) on alcohol-induced toxicity in rats was evaluated. In rats administered alcohol and ascorbic acid, malondialdehyde (MDA), hydroperoxide and conjugated dienes decreased in comparison with that given alcohol alone. The reduced activities of scavenging enzymes, e.g. superoxide dismutase (SOD) and catalase, in ethanol-administered rats were also enhanced by the co-administration of ascorbic acid and ethanol. Co-administration of ethanol and ascorbic acid reduced phospholipids and MDA levels of the erythrocyte membrane in comparison with that of the ethanol fed rats. The reduction in the activities of glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamaglutamyl transpeptidase (GGT) and the decrease in triglycerides levels also clearly showed the protective action of ascorbic acid in reducing ethanol induced toxicity.
Authors:
M V Suresh; B Menon; M Indira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  44     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  401-10     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Kerala, Thiruvananthapuram-695 001.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Ascorbic Acid / blood,  pharmacology*
Catalase / drug effects,  metabolism
Central Nervous System Depressants / toxicity*
Cholesterol / blood
Ethanol / toxicity*
Fatty Acids, Nonesterified
Glutathione / drug effects,  metabolism
Lipid Peroxidation / drug effects*,  physiology
Male
Malondialdehyde / blood
Phospholipids / blood
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Triglycerides / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Central Nervous System Depressants; 0/Fatty Acids, Nonesterified; 0/Phospholipids; 0/Triglycerides; 50-81-7/Ascorbic Acid; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 64-17-5/Ethanol; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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