Document Detail

Effects of exogenous surfactant supplementation and partial liquid ventilation on acute lung injury induced by wood smoke inhalation in newborn piglets.
MedLine Citation:
PMID:  12682489     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the beneficial effects of exogenous surfactant supplementation (ESS) and partial liquid ventilation (PLV) in treating acute lung injury induced by wood smoke inhalation. DESIGN: A prospective, randomized, controlled, multigroup study. SETTING: An animal research laboratory at a medical center. SUBJECTS: Newborn piglets (n = 29; 1.80 +/- 0.06 kg) of either sex. INTERVENTIONS: Animals were ventilated with a tidal volume of 15 mL/kg, a rate of 30 breaths/min, a positive end-expiratory pressure of 5 cm H(2)O, and an Fio(2) of 1.0. After the induction of acute lung injury by wood smoke inhalation, animals were randomly assigned to receive either conventional mechanical ventilation (CMV) or PLV with or without ESS pretreatment. Animals were grouped as CMV, ESS-CMV, PLV, and ESS-PLV. MEASUREMENTS AND MAIN RESULTS: Arterial blood gases, cardiovascular hemodynamics, dynamic lung compliance, and total lung injury scores were measured. After smoke inhalation, all four groups displayed similar high arterial carboxyhemoglobin levels, low Pao(2) (<150 mm Hg), and low dynamic lung compliance (<66% of its baseline). In the CMV group, these deleterious conditions remained during the 4-hr observation period, and severe lung injury was noted histologically. All treatment groups demonstrated a significant increase in Pao(2) compared with the CMV group. In addition, both the PLV and ESS-PLV groups displayed significant improvements in dynamic lung compliance and in their histologic outcomes. Nevertheless, none of the variables measured in the PLV group differed from those measured in the ESS-PLV group. CONCLUSIONS: In a newborn piglet model of smoke inhalation injury, PLV or ESS improved oxygenation. PLV compared favorably with ESS in its greater improvements in lung compliance and lung pathology. However, the combined therapy of ESS and PLV was not clearly superior to PLV alone during the observation period.
Mei-Jy Jeng; Yu Ru Kou; Ching-Chung Sheu; Betau Hwang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  31     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-05-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1166-74     Citation Subset:  AIM; IM    
Institutes of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
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MeSH Terms
Acute Disease
Animals, Newborn
Biological Products*
Carbon Dioxide / blood
Carboxyhemoglobin / analysis
Hydrogen-Ion Concentration
Liquid Ventilation*
Oxygen / blood
Pulmonary Surfactants / therapeutic use*
Respiration, Artificial
Respiratory Distress Syndrome, Adult / blood,  etiology,  physiopathology,  therapy*
Smoke Inhalation Injury / blood,  physiopathology,  therapy*
Reg. No./Substance:
0/Biological Products; 0/Pulmonary Surfactants; 108778-82-1/beractant; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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