Document Detail

Effects of exogenous surfactant on lung pressure-volume characteristics during liquid ventilation.
MedLine Citation:
PMID:  8727565     Owner:  NLM     Status:  MEDLINE    
Total liquid ventilation (LV) lowers airway pressures and potentially reduces barotrauma in models of hyaline membrane disease. LV eliminates surface tension by eliminating the air-perfluorochemicals (PFC) interface but does not eliminate interfacial tension (IT) at the lung/PFC interface. We hypothesized that pretreatment with exogenous surfactant before LV would shift the overall pressure-volume (PV) curve to the left, compared with LV without surfactant. Sequential quasi-static PV curves were obtained in 10 excised lungs (saline, air, PFC), with one-half randomized to exogenous surfactant replacement before LV. Analysis revealed that maximal inflation pressures were reduced during LV compared with baseline air curves. Addition of exogenous surfactant to LV further reduced maximal inflation pressures. A novel approach was used to transform these PV curves to estimates of in situ IT-volume curves. Estimated maximal IT at 20 ml/kg in preterm lamb lungs on air inflation after surfactant was 51 mN/m, compared with 40 mN/m for LV alone and with 27 mN/m for the combination of surfactant and LV. We conclude that the IT-reducing properties of the PFC studied (perflubron) can be augmented through the use of exogenous surfactant.
P Tarczy-Hornoch; J Hildebrandt; E A Mates; T A Standaert; W J Lamm; W A Hodson; J C Jackson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1764-71     Citation Subset:  IM    
Department of Pediatrics, University of Washington, Seattle 98195, USA.
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MeSH Terms
Lung / drug effects,  physiology*
Pulmonary Alveoli / physiology
Respiratory System / drug effects*
Surface-Active Agents / pharmacology*
Reg. No./Substance:
0/Surface-Active Agents

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