Document Detail


Effects of exogenous fatty acids on growth and enterotoxin B formation by Staphylococcus aureus 14458 and its membrane mutant.
MedLine Citation:
PMID:  861846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Growth and enterotoxin B (SEB) formation by Staphylococcus aureus 14458 and its membrane mutant can be depressed or stimulated by addition of graded amounts of saturated or unsaturated fatty acid mixtures. Under some conditions depression of SEB formation is separable from growth inhibition. Individual fatty acids most active in altering growth and (or) SEB production have been identified. Small amounts of unsaturated fatty acid mixture not only antagonize some effects of saturated fatty acid mixtures, but also appear to potentiate inhibition of growth and SEB formation by the saturated fatty acid mixture. 2-Admantanone, a compound which increases cell membrane fluidity, strongly suppresses SEB formation while stimulating growth. The results are discussed in relation to possible effects of exogenous fatty acids on the composition of membrane phospholipids and attendant changes in SEB production.
Authors:
R A Altenbern
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  23     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  389-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adamantane / pharmacology
Cell Membrane / drug effects,  metabolism
Enterotoxins / biosynthesis*
Fatty Acids / pharmacology*
Fatty Acids, Unsaturated / pharmacology*
Mutation
Staphylococcus aureus / drug effects*,  growth & development,  metabolism
Chemical
Reg. No./Substance:
0/Enterotoxins; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 281-23-2/Adamantane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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