Document Detail

Effects of exocrine pancreatic insufficiency and replacement therapy on the bacterial flora of the duodenum in dogs.
MedLine Citation:
PMID:  2301831     Owner:  NLM     Status:  MEDLINE    
The influence of pancreatic secretions on the bacterial flora of the small intestine in 6 dogs was investigated by determining effects of exocrine pancreatic insufficiency on numbers and types of bacteria in duodenal juice, and by examining the subsequent response to dietary supplementation with bovine pancreatic extract. Exocrine pancreatic insufficiency was induced by ligation of pancreatic ducts and was confirmed by indirect assessment of exocrine pancreatic function. Duct ligation was followed by large increases (P less than 0.01) in total numbers of bacteria, reflecting increased numbers particularly of Lactobacillus spp and Streptococcus spp, in 3 dogs accompanied by obligate anaerobes. Total numbers of aerobes and anaerobes decreased markedly (P less than 0.05) after supplementation with bovine pancreatic extract to values that were not significantly different from those determined before duct ligation. Exocrine pancreatic insufficiency therefore resulted in small intestinal bacterial overgrowth that was reversed by pancreatic replacement therapy, indicating that pancreatic secretions can have an important influence on the small intestinal bacterial flora of dogs.
K W Simpson; R M Batt; D Jones; D B Morton
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  51     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-15     Completed Date:  1990-03-15     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Biomedical Services, University of Leicester, UK.
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MeSH Terms
Colony Count, Microbial / veterinary
Duodenum / microbiology*
Enterobacteriaceae / growth & development
Exocrine Pancreatic Insufficiency / microbiology,  veterinary*
Intestinal Secretions / microbiology*
Lactobacillus / growth & development*
Pancreatic Extracts
Species Specificity
Staphylococcus / growth & development
Streptococcus / growth & development*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Pancreatic Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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