| Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. | |
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MedLine Citation:
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PMID: 19491293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regular physical activity improves glucose tolerance and decreases adiposity. Our aim was to investigate the effects of exercise training on subcutaneous (inguinal) and visceral (parametrial) adipose tissue in rats that were fed a chow diet (13% fat) or made insulin resistant by a high-fat diet (60% fat). Sprague-Dawley rats performed 4 wk of voluntary wheel running or were kept as sedentary controls. The training groups fed chow and the high-fat diet achieved similar running distances (8.8 +/- 1.8 and 9.3 +/- 1.9 km/day, respectively). Training improved oral glucose tolerance in chow-fed rats and prevented the glucose intolerance that occurred in sedentary rats fed the high-fat diet. In both subcutaneous and visceral adipose tissue, the high-fat diet-induced increases in fat pad weight (67% and 133%, respectively), adipocyte size (20% and 43%), and cell number (36% and 65%) were completely prevented by exercise training. Cytokine mRNA expression in visceral fat did not change with exercise training. However, in subcutaneous fat, training actually increased mRNA expression of several cytokines [IL-6: 80% (P < 0.05); TNF-alpha: 100% (P < 0.05); IL-1 receptor antagonist (IL-1Ra): 57% (P = 0.08)] with no detectable increases in serum cytokine concentrations. In summary, exercise training can overcome high-fat diet-induced impairments in glucose tolerance and increases in adipocyte size, cell number, and fat pad mass. Improved glucose tolerance was accompanied by an increase in cytokine gene expression in subcutaneous fat. This finding raises the possibility of a specific role of subcutaneous adipose tissue in adaptive responses to exercise training. |
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Authors:
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Katja S C Gollisch; Josef Brandauer; Niels Jessen; Taro Toyoda; Ali Nayer; Michael F Hirshman; Laurie J Goodyear |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-06-02 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 297 ISSN: 1522-1555 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-23 Completed Date: 2009-08-18 Revised Date: 2010-09-24 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E495-504 Citation Subset: IM |
Affiliation:
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Research Division, Department of Medicine, and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / physiology Body Weight / physiology Diet, Atherogenic* Dietary Fats / pharmacology* Eating / physiology Female Intra-Abdominal Fat / anatomy & histology, drug effects, metabolism, physiology* Liver / metabolism Muscle, Skeletal / metabolism Organ Size Physical Conditioning, Animal / physiology* Rats Rats, Sprague-Dawley Running Subcutaneous Fat / anatomy & histology, drug effects, metabolism, physiology* Triglycerides / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P30-DK-36836/DK/NIDDK NIH HHS; R01-DK-06862/DK/NIDDK NIH HHS; T32-DK-07260-29/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats; 0/Triglycerides |
| Comments/Corrections | |
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