| Effects of exercise training on molecular markers of lipogenesis and lipid partitioning in fructose-induced liver fat accumulation. | |
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MedLine Citation:
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PMID: 21860785 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study was designed to investigate the impact of exercise training on lipogenic gene expression in liver and lipid partitioning following the ingestion of a high fructose load. Female rats were exercise-trained for 8 wk or kept sedentary before being submitted to a fasting/refeeding protocol. Rats were further subdivided as follow: rats were fasted for 24 h, refed a standard diet for 24 h, starved for another 24 h, and refed with a standard or a high-fructose diet 24 h before sacrifice. Fructose refeeding was associated with an increase in hepatic lipid content, endocannabinoid receptor 1, sterol regulatory element-binding protein1c, and stearoyl-CoA desaturase1 gene expression in both Sed and TR rats. However, desaturation indexes measured in liver (C16 : 1/C16 : 0 and C18 : 1/C18 : 0) and plasma (C18 : 1/C18 : 0) were higher (P < 0.01) in TR than in Sed rats following fructose refeeding. It is concluded that exercise training does not significantly affect fat accumulation and the molecular expression of genes involved in lipogenesis after fasting and fructose refeeding but does modify the partitioning of lipids so as to provide more unsaturated fatty acids in liver without affecting liver fat content. |
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Authors:
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Siham Yasari; Denis Prud'homme; Frédérique Tesson; Marek Jankowski; Jolanta Gutkowska; Emile Levy; Jean-Marc Lavoie |
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Publication Detail:
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Type: Journal Article Date: 2011-08-10 |
Journal Detail:
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Title: Journal of nutrition and metabolism Volume: 2012 ISSN: 2090-0732 ISO Abbreviation: J Nutr Metab Publication Date: 2012 |
Date Detail:
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Created Date: 2011-08-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526296 Medline TA: J Nutr Metab Country: United States |
Other Details:
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Languages: eng Pagination: 181687 Citation Subset: - |
Affiliation:
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Department of Kinesiology, University of Montreal, C.P. 6128, Succursale Centre-Ville, Montréal , QC, Canada H3C 3J7. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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